J
Jean-Louis Milan
Researcher at Aix-Marseille University
Publications - 27
Citations - 597
Jean-Louis Milan is an academic researcher from Aix-Marseille University. The author has contributed to research in topics: Cytoskeleton & Focal adhesion. The author has an hindex of 9, co-authored 24 publications receiving 416 citations. Previous affiliations of Jean-Louis Milan include Polytechnic University of Catalonia.
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Journal ArticleDOI
Curvotaxis Directs Cell Migration Through Cell-Scale Curvature Landscapes
Laurent Pieuchot,Julie Marteau,Alain Guignandon,Thomas Dos Santos,Isabelle Brigaud,P.-F. Chauvy,Thomas Cloatre,Arnaud Ponche,Tatiana Petithory,Pablo Rougerie,Maxime Vassaux,Jean-Louis Milan,Nayana Tusamda Wakhloo,Arnaud Spangenberg,Maxence Bigerelle,Karine Anselme +15 more
TL;DR: It is shown that the cell nucleus and cytoskeleton cooperate to guide cells to concave valleys in a process they coin curvotaxis, a new cellular ability that enables the cells to respond to cell-scale curvature variations, a ubiquitous trait of cellular biotopes.
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Computational modelling of the mechanical environment of osteogenesis within a polylactic acid–calcium phosphate glass scaffold
TL;DR: Results of the model show that during perfusion test an inlet velocity of 25 microm/s generates on scaffold surface a fluid flow shear stress which may stimulate osteogenesis and values one order of magnitude higher may be detrimental for cells.
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Topology optimization and additive manufacturing: Comparison of conception methods using industrial codes
TL;DR: In this paper, the authors proposed to use topology optimization and additive manufacturing to construct a metal cube subjected to a given pressure, which was then used to produce three different structures.
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Simulation of bone tissue formation within a porous scaffold under dynamic compression
TL;DR: The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.
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Stem cell mechanical behaviour modelling: substrate's curvature influence during adhesion.
Maxime Vassaux,Jean-Louis Milan +1 more
TL;DR: Findings achieved using a verified virtual testing methodology, in particular regarding the nucleus stability, might be of significant importance with respect to the division and differentiation of mesenchymal stem cells.