Jean-Luc Montchamp

TL;DR: This Account discusses the previously neglected potential of these phosphinates as replacements of PCl3 for the preparation of organophosphorus compounds and examines the use of transition metal-catalyzed reactions such as cross-coupling and hydrophosphinylation for phosphorus-carbon bond formation.

TL;DR: Various palladium catalysts promote the addition of hypophosphorous derivatives ROP(O)H(2) to alkenes and alkynes in good yields and under mild conditions.

TL;DR: The reactions of phosphinylidene-containing compounds with unactivated unsaturated hydrocarbons are reviewed and free-radical and metal-catalyzed additions of R(1)R(2)P(O)H to alkenes, alkynes, and related compounds, deliver functionalized organophosphorus compounds RP(O), including H-phosphinates, phosphinates, tertiary phosphines, and phosphonates.

TL;DR: The work in this article summarizes the research conducted in our laboratory over the past five years, with a focus on the reactions of hypophosphorous acid derivatives, including room-temperature radical addition and palladium-catalyzed addition.

TL;DR: A novel and practical approach to monosubstituted phosphinic acid (alkylphosphonous acid) derivatives from hypophosphite salts or esters is described, which tolerates a wide range of functional groups and can be prepared in a single step from cheap starting materials.