J
Jean-Luc Puel
Researcher at University of Montpellier
Publications - 173
Citations - 8689
Jean-Luc Puel is an academic researcher from University of Montpellier. The author has contributed to research in topics: Cochlea & Hair cell. The author has an hindex of 49, co-authored 168 publications receiving 7981 citations. Previous affiliations of Jean-Luc Puel include University Medical Center New Orleans & Louisiana State University.
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Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss.
TL;DR: The high degree of protection observed with kynurenate attests that dendritic damage is an important component in noise-induced hearing loss and demonstrates that a synaptic repair mechanism occurring within the first few days post-exposure is partly responsible for the recovery of temporary threshold shifts after an acoustic trauma.
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A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.
TL;DR: Results indicate that the MAPK–JNK signal pathway is involved in both ototoxicity and acoustic trauma-induced hair cell loss and permanent hearing loss.
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Salicylate induces tinnitus through activation of cochlear NMDA receptors
TL;DR: Application of NMDA antagonists into the perilymphatic fluids of the cochlea blocked the increase in pole-jumping behavior induced by salicylate, suggesting that salicyllate induces tinnitus through activation of cochlear NMDA receptors.
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Chemical synaptic transmission in the cochlea.
TL;DR: Understanding the subtle molecular mechanisms which underly the control of neuronal excitability, synaptic plasticity and neuronal death in cochlear function and disease is a very important issue for the development of future therapies.
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Excitotoxicity, synaptic repair, and functional recovery in the mammalian cochlea: a review of recent findings.
Rémy Pujol,Jean-Luc Puel +1 more
TL;DR: A local (transtympanic) strategy against cochlear excitotoxicity may, in the near future, prove to be helpful in ischemic‐ or noise‐induced sudden deafness, as well as in the related tinnitus.