J
Jean-Michel Bruneau
Publications - 5
Citations - 168
Jean-Michel Bruneau is an academic researcher. The author has contributed to research in topics: Integrase & Allosteric regulation. The author has an hindex of 3, co-authored 5 publications receiving 134 citations.
Papers
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Journal ArticleDOI
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Erwann Le Rouzic,Damien Bonnard,Sophie Chasset,Jean-Michel Bruneau,Francis Chevreuil,Frédéric Le Strat,Juliette Nguyen,Roxane Beauvoir,Céline Amadori,Julie Brias,Sophie Vomscheid,Sylvia Eiler,Nicolas Levy,Olivier Delelis,Eric Deprez,Ali Saïb,Alessia Zamborlini,Stéphane Emiliani,Marc Ruff,Benoit Ledoussal,François Moreau,Richard Benarous +21 more
TL;DR: The crystal structure of Mut101 in complex with IN is determined and it is shown that the compound binds to the LEDGF-binding pocket, promoting conformational changes of IN which explain at the atomic level the allosteric effect of the IN/LEDGF interaction inhibitor on IN functions.
Journal ArticleDOI
Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
Damien Bonnard,Erwann Le Rouzic,Sylvia Eiler,Céline Amadori,Igor Orlov,Jean-Michel Bruneau,Julie Brias,Julien Barbion,Francis Chevreuil,Danièle Spehner,Sophie Chasset,Benoit Ledoussal,François Moreau,Ali Saïb,Bruno P. Klaholz,Stéphane Emiliani,Marc Ruff,Alessia Zamborlini,Richard Benarous +18 more
TL;DR: This study reveals that affinity for the LEDGF/p75-binding pocket is not sufficient to induce INLAI-dependent IN multimerization and the associated inhibition of viral maturation.
Journal ArticleDOI
Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
Nicolas Levy,Jean-Michel Bruneau,E. Le Rouzic,Damien Bonnard,F. Le Strat,Audrey Caravano,Francis Chevreuil,Julien Barbion,Sophie Chasset,Benoit Ledoussal,François Moreau,Marc Ruff +11 more
TL;DR: Examination of the structure of the E. coli PBP2 in its Apo form and upon its reaction with 2 diazabicyclo derivatives, avibactam and CPD4, a new potent P BP2 inhibitor shows that unlike avibactsam, C PD4 can perform a hydrophobic stacking on Trp370 in the active site of E. bacteria.
Patent
Method of producing an inactivated lentivirus, especially HIV, vaccine, kit and method of use
TL;DR: In this article, a method for producing an immunogenic composition or vaccine comprising inactivated lentivirus, in particular inactivated HIV, where producer cells producing, preferably constituvely producing Lentivirus particles are provided, the lentiv virus particles are produced by these producer cells in the presence of an antiretroviral (ARV) agent which is an inhibitor of the IN-LEDGF/p75 interaction.