B
Bruno P. Klaholz
Researcher at University of Strasbourg
Publications - 89
Citations - 5916
Bruno P. Klaholz is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Eukaryotic Ribosome & Initiation factor. The author has an hindex of 32, co-authored 82 publications receiving 4644 citations. Previous affiliations of Bruno P. Klaholz include Centre national de la recherche scientifique & French Institute of Health and Medical Research.
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Journal ArticleDOI
The Crystal Structure of the Nuclear Receptor for Vitamin D Bound to Its Natural Ligand
TL;DR: The 1.8 A resolution crystal structure of the complex between a VDR ligand-binding domain (LBD) construct lacking the highly variable VDR-specific insertion domain and vitamin D shows that the N-terminal part of the LBD is essential for its structural and functional integrity while the large insertion peptide is dispensable.
Journal ArticleDOI
New tools for the analysis and validation of cryo-EM maps and atomic models
Pavel V. Afonine,Pavel V. Afonine,Bruno P. Klaholz,Nigel W. Moriarty,Billy K. Poon,Oleg V. Sobolev,Thomas C. Terwilliger,Paul D. Adams,Paul D. Adams,Alexandre Urzhumtsev,Alexandre Urzhumtsev +10 more
TL;DR: New methods and PHENIX tools for quality assessment of cryo-EM maps, atomic models and model-to-map fitting are presented and results of systematic application of these tools to high-resolution cryospecies maps and corresponding atomic models are analyzed and discussed.
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Structure of the human 80S ribosome
TL;DR: The near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building is reported and reveals atomic details of the subunit interface, which is seen to remodel strongly upon rotational movements of the ribosomal subunits.
Journal ArticleDOI
N 6- Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
Honghui Ma,Honghui Ma,Honghui Ma,Xiaoyun Wang,Jia-Bin Cai,Qing Dai,Qing Dai,S. Kundhavai Natchiar,Ruitu Lv,Kai Chen,Kai Chen,Zhike Lu,Zhike Lu,Hao Chen,Yujiang Geno Shi,Yujiang Geno Shi,Fei Lan,Jia Fan,Bruno P. Klaholz,Tao Pan,Yang Shi,Yang Shi,Chuan He,Chuan He +23 more
TL;DR: A new m6A methyltransferase, ZCCHC4, is reported, which primarily methylates human 28S rRNA and also interacts with a subset of mRNAs, and was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m 6A 4220 in 28s rRNA.
ComponentDOI
Visualization of chemical modifications in the human 80S ribosome structure.
TL;DR: A high-resolution structure of the human 80S ribosome determined by cryo-electron microscopy is determined that has sufficient resolution to map more than 130 rRNA modifications, some of which were unknown, and suggests the possibility of designing more specific ribo-targeting drugs.