B
Bruno Giros
Researcher at McGill University
Publications - 236
Citations - 26461
Bruno Giros is an academic researcher from McGill University. The author has contributed to research in topics: Dopamine & Dopamine transporter. The author has an hindex of 70, co-authored 230 publications receiving 25066 citations. Previous affiliations of Bruno Giros include University of Paris & French Institute of Health and Medical Research.
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Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.
TL;DR: The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions, and seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease.
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Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
TL;DR: In homozygote mice, dopamine persists at least 100 times longer in the extracellular space, explaining the biochemical basis of the hyperdopaminergic phenotype and demonstrating the critical role of the transporter in regulating neurotransmission.
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Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
Stéphane Jamain,Hélène Quach,Catalina Betancur,Maria Råstam,Catherine Colineaux,I. Carina Gillberg,Henrik Soderstrom,Bruno Giros,Marion Leboyer,Christopher Gillberg,Thomas Bourgeron +10 more
TL;DR: The authors reported mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism spectrum disorders, which affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
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Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA.
Marie-Louise Bouthenet,Evelyne Souil,Marie-Pascale Martres,Pierre Sokoloff,Bruno Giros,J C Schwartz +5 more
TL;DR: D2 and D3 receptor mRNAs were also detected at the level of the substantia nigra, suggesting that these receptors function as both autoreceptor and postsynaptic receptors, the latter being most abundant in dopaminergic areas known to be associated with cognitive and emotional functions.
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Alternative splicing directs the expression of two D2 dopamine receptor isoforms
Bruno Giros,Pierre Sokoloff,Marie-Pascale Martres,Jean-François Riou,Laurent Emorine,Jean-Charles Schwartz +5 more
TL;DR: It is shown that the gene for the D2 receptor produces two receptor isoforms by alternative messenger RNA splicing, providing a route to receptor diversity in this family of receptors.