J
Jeanine Fontaine
Researcher at Université libre de Bruxelles
Publications - 54
Citations - 996
Jeanine Fontaine is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Diazoxide & Potassium channel. The author has an hindex of 19, co-authored 54 publications receiving 968 citations. Previous affiliations of Jeanine Fontaine include Free University of Brussels.
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Journal ArticleDOI
Preparation of poly(N-isopropylacrylamide) copolymers and preliminary assessment of their acute and subacute toxicity in mice
Hugues Malonne,Frédéric Eeckman,David Fontaine,Anne Otto,Louis De Vos,André Jules Moes,Jeanine Fontaine,Karim Amighi +7 more
TL;DR: PNIPAAm-co-NVA is well tolerated up to 4000 mg/kg body weight when administered orally, indicating the absence of cumulative toxicity and a no-observed-adverse-effect level (NOAEL) of 2000mg/kg was identified for PNipAAm and its two copolymers.
Journal ArticleDOI
Expression of vascular endothelial growth factor (VEGF) and VEGF receptors in human neuroblastomas.
Ingrid Langer,Pascale Vertongen,Jason Perret,Jeanine Fontaine,Ghanem Atassi,Patrick Robberecht +5 more
TL;DR: The results suggest that, in addition to its effect on angiogenesis, VEGF may affect neuroblastoma cell growth directly and could be an autocrine growth factor.
Journal ArticleDOI
3-(Alkylamino)-4h-Pyrido[4,3-E]-1,2,4-Thiadiazine 1,1-Dioxides as Powerful Inhibitors of Insulin Release from Rat Pancreatic B-Cells: A New Class of Potassium Channel Openers?
Bernard Pirotte,Pascal De Tullio,Philippe Lebrun,M. H. Antoine,Jeanine Fontaine,Bernard Masereel,Marc Schynts,Léon Dupont,André Herchuelz,Jacques Delarge +9 more
Journal ArticleDOI
3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships
Pascal De Tullio,Bernard Pirotte,Philippe Lebrun,Jeanine Fontaine,L. Dupont,Marie-Hélène Antoine,Raogo Ouedraogo,Smail Khelili,Carine Maggetto,Bernard Masereel,Ousmane Diouf,and Tchao Podona,Jacques Delarge +12 more
TL;DR: Three 4-N-unsubstituted 3-(alkylamino)-4H-pyrido[4,3-e]-1,2,4,-thiadiazine 1,1-dioxides may serve as pharmacological tools in studying the K(ATP) channels ("pancreatic-like") in other tissues.
Journal ArticleDOI
3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.
Bernard Pirotte,Raogo Ouedraogo,Pascal De Tullio,S. Khelili,Fabian Somers,Stéphane Boverie,Léon Dupont,Jeanine Fontaine,Jacques Damas,Philippe Lebrun +9 more
TL;DR: It is suggested that 3-alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1, 1-dioxides may be considered as new examples of K(ATP) channel openers expressing a pharmacological profile similar to that of pinacidil and diazoxide.