L
L. Dupont
Researcher at Université libre de Bruxelles
Publications - 47
Citations - 283
L. Dupont is an academic researcher from Université libre de Bruxelles. The author has contributed to research in topics: Crystal structure & Bicyclic molecule. The author has an hindex of 8, co-authored 47 publications receiving 268 citations.
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4H-1,2,4-Pyridothiadiazine 1,1-Dioxides and 2,3-Dihydro-4H-1,2,4-pyridothiadiazine 1,1-Dioxides Chemically Related to Diazoxide and Cyclothiazide as Powerful Positive Allosteric Modulators of (R/S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors: Design, Synthesis, Pharmacology, and Structure−Activity Relationships
Bernard Pirotte,Tchao Podona,Ousmane Diouf,Pascal De Tullio,Philippe Lebrun,L. Dupont,Fabian Somers,Jacques Delarge,Philippe Morain,Pierre Lestage,Jean Lepagnol,Michael Spedding +11 more
TL;DR: 31b appeared to be more specific than diazoxide as an AMPA receptor modulator, and may be considered as a new pharmacological tool, different from diazox and cyclothiazide, for studying AMPA receptors.
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3- and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation and structure-activity relationships
Pascal De Tullio,Bernard Pirotte,Philippe Lebrun,Jeanine Fontaine,L. Dupont,Marie-Hélène Antoine,Raogo Ouedraogo,Smail Khelili,Carine Maggetto,Bernard Masereel,Ousmane Diouf,and Tchao Podona,Jacques Delarge +12 more
TL;DR: Three 4-N-unsubstituted 3-(alkylamino)-4H-pyrido[4,3-e]-1,2,4,-thiadiazine 1,1-dioxides may serve as pharmacological tools in studying the K(ATP) channels ("pancreatic-like") in other tissues.
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Original 2-Alkylamino-6-halogenoquinazolin-4(3H)-ones and KATP Channel Activity
Fabian Somers,Raogo Ouedraogo,Marie-Hélène Antoine,Pascal De Tullio,B. Becker,Jeanine Fontaine,Jacques Damas,L. Dupont,Benoît Rigo,Jacques Delarge,Philippe Lebrun,Bernard Pirotte +11 more
TL;DR: In conclusion, the newly synthesized quinazolinones interfere with insulin secretion and smooth muscle contractile activity and lack tissue selectivity.
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Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.
Pascal De Tullio,L. Dupont,Francotte Pierre,Stéphane Counerotte,Philippe Lebrun,Bernard Pirotte +5 more
TL;DR: These models highlighted the importance of several chemical regions for KATP channel activation and could be very helpful for future improvement of drug potency, selectivity, or both.