J
Jeanne M.M. Tan
Researcher at National University of Singapore
Publications - 14
Citations - 1853
Jeanne M.M. Tan is an academic researcher from National University of Singapore. The author has contributed to research in topics: Parkin & Ubiquitin ligase. The author has an hindex of 12, co-authored 14 publications receiving 1734 citations. Previous affiliations of Jeanne M.M. Tan include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1 : implications for Lewy body formation
Kah-Leong Lim,Katherine C. M. Chew,Jeanne M.M. Tan,Cheng Wang,Kenny K.K. Chung,Yi Zhang,Yuji Tanaka,Yuji Tanaka,Wanli W. Smith,Simone Engelender,Christopher A. Ross,Valina L. Dawson,Ted M. Dawson +12 more
TL;DR: The results suggest that parkin is a dual-function ubiquitin ligase and that K63-linked ubiquitination of synphilin-1 by parkin may be involved in the formation of Lewy body inclusions associated with PD.
Journal ArticleDOI
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases
Jeanne M.M. Tan,Esther Wong,Donald S. Kirkpatrick,Olga Pletnikova,Han Seok Ko,Shiam Peng Tay,Michelle W L Ho,Juan C. Troncoso,Steven P. Gygi,Michael K. Lee,Valina L. Dawson,Ted M. Dawson,Kah-Leong Lim +12 more
TL;DR: The results provide a novel mechanistic route that underlies the life cycle of an inclusion body and indicate that K63-linked ubiquitin chains may represent a common denominator underlying inclusions biogenesis, as well as a general cellular strategy for defining cargo destined for the autophagic system.
Journal ArticleDOI
Autophagy-mediated clearance of aggresomes is not a universal phenomenon
Esther Wong,Jeanne M.M. Tan,Wen E. Soong,Kamila Hussein,Nobuyuki Nukina,Dawson Valina,Ted M. Dawson,Ana Maria Cuervo,Kah-Leong Lim +8 more
TL;DR: The results demonstrate that not all aggresomes are efficiently primed for autophagic clearance and highlight a certain degree of selectivity for the supposedly non-discriminative pathway.
Journal ArticleDOI
Alterations in the solubility and intracellular localization of parkin by several familial Parkinson's disease-linked point mutations.
Cheng Wang,Jeanne M.M. Tan,Michelle W L Ho,Norazean Zaiden,Siew Heng Wong,Constance L. C. Chew,Pei Woon Eng,Tit Meng Lim,Ted M. Dawson,Kah-Leong Lim +9 more
TL;DR: It is suggested that alterations in parkin solubility and intracellular localization may underlie the molecular basis of the loss of function caused by several of its mutations.
Journal ArticleDOI
Role of the ubiquitin proteasome system in Parkinson's disease
Kah-Leong Lim,Jeanne M.M. Tan +1 more
TL;DR: Current thoughts and controversies about the relationship between the ubiquitin proteasome system and Parkinson's disease are reviewed and whether strategies aimed at mitigating UPS dysfunction could represent rational ways to intervene in the disease are discussed.