H
Han Seok Ko
Researcher at Johns Hopkins University School of Medicine
Publications - 71
Citations - 11203
Han Seok Ko is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Parkin & Neurodegeneration. The author has an hindex of 34, co-authored 67 publications receiving 8984 citations. Previous affiliations of Han Seok Ko include Hokkaido University & Johns Hopkins University.
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Journal ArticleDOI
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza,Chun Zhou,Yong Huang,Mei Cui,Rosa L.A. de Vries,Jiho Kim,Jessica May,Maja Aleksandra Tocilescu,Wencheng Liu,Han Seok Ko,Jordi Magrané,Darren J. Moore,Darren J. Moore,Valina L. Dawson,Regis Grailhe,Ted M. Dawson,Chenjian Li,Kim Tieu,Serge Przedborski +18 more
TL;DR: It is suggested that Parkin, together with PINK1, modulates mitochondrial trafficking, especially to the perinuclear region, a subcellular area associated with autophagy, which may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease.
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PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson’s Disease
Joo Ho Shin,Han Seok Ko,Hochul Kang,Yunjong Lee,Yun Il Lee,Olga Pletinkova,Juan C. Troconso,Valina L. Dawson,Ted M. Dawson +8 more
TL;DR: The identification of PARIS provides a molecular mechanism for neurodegeneration due to parkin inactivation, whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitIn ligase, parkin.
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Genetic animal models of Parkinson's disease.
TL;DR: The animal models for these genetic causes of PD, including mutations in LRRK2 and alpha-synuclein and mutations in parkin, DJ-1, and PINK1, are discussed, their limitations, and value.
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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease.
Sangjune Kim,Seung-Hwan Kwon,Tae In Kam,Nikhil Panicker,Senthilkumar S. Karuppagounder,Saebom Lee,Jun Hee Lee,Wonjoong Richard Kim,Minjee Kook,Catherine A. Foss,Chentian Shen,Hojae Lee,Subhash Kulkarni,Pankaj J. Pasricha,Gabsang Lee,Martin G. Pomper,Valina L. Dawson,Ted M. Dawson,Han Seok Ko +18 more
TL;DR: This study supports the Braak hypothesis in the etiology of idiopathic Parkinson's disease by assessing α- synucleinopathy in the brain in a novel gut-to-brain α-syn transmission mouse model, where pathologicalα-syn preformed fibrils were injected into the duodenal and pyloric muscularis layer.
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
Seung Pil Yun,Tae In Kam,Nikhil Panicker,SangMin Kim,Yumin Oh,Jong-Sung Park,Seung-Hwan Kwon,Yong Joo Park,Senthilkumar S. Karuppagounder,Hyejin Park,Sangjune Kim,Nayeon Oh,Nayoung Alice Kim,Saebom Lee,Saurav Brahmachari,Xiaobo Mao,Jun Hee Lee,Manoj Kumar,Daniel An,Sung Ung Kang,Yunjong Lee,Kang Choon Lee,Dong Hee Na,Dong-Hoon Kim,Sang Hun Lee,Viktor V. Roschke,Shane A. Liddelow,Zoltan Mari,Ben A. Barres,Valina L. Dawson,Seulki Lee,Ted M. Dawson,Han Seok Ko +32 more
TL;DR: It is found that NLY01 is a potent GLP1R agonist with favorable properties that is neuroprotective through the direct prevention of microglia-mediated conversion of astrocytes to an A1 neurotoxic phenotype and should be evaluated in the treatment of Parkinson’s disease and related neurologic disorders characterized by microglial activation.