Jeeva Munasinghe

TL;DR: Fenton-reaction-acceleratable magnetic nanoparticles, i.e., cisplatin (CDDP)-loaded Fe3O4/Gd2O3 hybrid nanoparticles with conjugation of lactoferrin (LF) and RGD dimer (RGD2), were exploited in this study for FT of orthotopic brain tumors and led to significant inhibition of tumor growth.

TL;DR: The MR Imaging and chemotherapy results on the cancer cells and tumor-bearing mice reinforce that the DOX@ES-MION3@RGD2@mPEG3 nanoparticles are promising for high-resolution T1-weighted MR imaging and precise chemotherapy of tumors.

TL;DR: The ability to control the roughness and nanoscale porosity of gold nanoshells by using redox-active polymer poly(vinylphenol)-b-(styrene) nanoparticles as reducing agent and template and by taking advantage of the sharp branches and nanoporous features is demonstrated.

TL;DR: The findings suggest that longitudinal and noninvasive monitoring of tumor pO(2) makes it possible to identify a window of vascular renormalization to maximize the effects of combination therapy with antiangiogenic drugs.

TL;DR: The use of pulsed electron paramagnetic resonance imaging (EPRI) is illustrated as a novel imaging method to directly monitor fluctuations in oxygen concentrations in mouse models and suggests that the fluctuation in pO(2) correlated with pericyte density rather than vascular density in the tumor.