J
Jeffery S. Carter
Researcher at G. D. Searle & Company
Publications - 16
Citations - 3929
Jeffery S. Carter is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Benzopyran & Trifluoromethyl. The author has an hindex of 13, co-authored 16 publications receiving 3778 citations.
Papers
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
John J. Talley,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Carol M. Koboldt,Jaime L. Masferrer,William E. Perkins,Roland S. Rogers,Alexander F. Shaffer,Yan Y. Zhang,Ben S. Zweifel,Karen Seibert +11 more
Patent
Substituted isoxazoles for the treatment of inflammation
David L. Brown,Jeffery S. Carter,Paul W. Collins,Matthew J. Graneto,Srinivasan Nagarajan,Richard Partis,Roland S. Rogers,Karen Seibert,Stealey Michael A,John J. Talley,Richard M. Weier,Xiangdong Xu +11 more
TL;DR: A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders as discussed by the authors, which are defined by Formula (III) whrein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxyalky, lower alkoxy carbonyl, lower aralkyl; and wherein R8 is one or more radicals independently selected from Hydrido, lower Alkylsulfinyl, lower ALkyL, cyano, caroxynine, Carboxyl and Car
Patent
Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation
John J. Talley,Thomas D. Penning,Paul W. Collins,Donald J. Rogier,James W. Malecha,Julie M. Miyashiro,Stephen R. Bertenshaw,Ish K. Khanna,Matthew J. Graneto,Roland S. Rogers,Jeffery S. Carter,Stephen H. Docter,Stella S. Yu +12 more
TL;DR: A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders in this paper, where the compounds of particular interest are defined by formula (II).
Journal ArticleDOI
N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.
John J. Talley,Stephen R. Bertenshaw,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Michael S. Kellogg,Carol M. Koboldt,Jinhua Yuan,Yan Y. Zhang,Karen Seibert +9 more