C
Carol M. Koboldt
Researcher at G. D. Searle & Company
Publications - 26
Citations - 4167
Carol M. Koboldt is an academic researcher from G. D. Searle & Company. The author has contributed to research in topics: Sulfone & Sulfonamide. The author has an hindex of 17, co-authored 26 publications receiving 3996 citations. Previous affiliations of Carol M. Koboldt include Pharmacia.
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Journal ArticleDOI
Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).
T. D. Penning,John J. Talley,Bertenshaw,Jeffery S. Carter,P. W. Collins,Stephen H. Docter,Matthew J. Graneto,Len F. Lee,James W. Malecha,Julie M. Miyashiro,Roland S. Rogers,D. J. Rogier,Stella S. Yu,AndersonGD,E. G. Burton,J. N. Cogburn,Susan A. Gregory,Carol M. Koboldt,W E Perkins,Karen Seibert,A. W. Veenhuizen,Yan Y. Zhang,P. C. Isakson +22 more
TL;DR: 1i (4-[5-(4-methylphenyl)-3-(trifluoromethyl)- H-pyrazol-1-yl]benzenesulfonamide, SC-58635, celecoxib), which is currently in phase III clinical trials for the treatment of rheumatoid arthritis and osteoarthritis, is identified.
Journal ArticleDOI
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
John J. Talley,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Carol M. Koboldt,Jaime L. Masferrer,William E. Perkins,Roland S. Rogers,Alexander F. Shaffer,Yan Y. Zhang,Ben S. Zweifel,Karen Seibert +11 more
Journal ArticleDOI
A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors.
James K. Gierse,Joseph J. McDonald,Scott D. Hauser,Shaukat H. Rangwala,Carol M. Koboldt,Karen Seibert +5 more
TL;DR: It is indicated that the single amino acid substitution of isoleucine at position 509 for a valine is sufficient to confer COX-2 selectivity in this example of a diaryl-heterocycle COX inhibitor.
Journal ArticleDOI
N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.
John J. Talley,Stephen R. Bertenshaw,David L. Brown,Jeffery S. Carter,Matthew J. Graneto,Michael S. Kellogg,Carol M. Koboldt,Jinhua Yuan,Yan Y. Zhang,Karen Seibert +9 more
Journal ArticleDOI
1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.
Ish K. Khanna,Richard M. Weier,Yu Yi,Paul W. Collins,Julie M. Miyashiro,Carol M. Koboldt,A. W. Veenhuizen,Jerry L. Currie,Karen Seibert,Peter C. Isakson +9 more
TL;DR: In vivo testing in the carrageenan-induced paw edema model in the rat establishes that the 1,2-diarylpyrroles are orally active antiinflammatory agents.