Jeffrey A. Gold

TL;DR: It is shown that lipopolysaccharide from Gram-negative bacteria activates interleukin-5 (IL-5)- or interferon-γ–primed eosinophils to release mitochondrial DNA in a reactive oxygen species–dependent manner, but independent of eosInophil death, suggesting a previously undescribed mechanism of eOSinophil-mediated innate immune responses that might be crucial for maintaining the intestinal barrier function after inflammation-associated epithelial cell damage

TL;DR: New guidelines emphasizing escalating bolus doses of diazepam, and barbiturates if necessary, significantly reduced the need for mechanical ventilation and showed trends toward reductions in ICU length of stay and nosocomial infections.

TL;DR: This article reviews the pathophysiology, diagnosis, and treatment of alcohol withdrawal syndromes in the intensive care unit as well as the literature on the optimal pharmacologic strategies for treatment of Alcohol withdrawal syndrome in the critically ill.

TL;DR: A differential role for CD80 and CD86 in regulation of inflammation in the innate immune response to sepsis is described, suggesting a divergent role for these receptors.

TL;DR: These data demonstrate a central role for CD40 and CD80/86 in the innate immune response and suggest that combined inhibition of CD 40 and CD 80/86 may improve mortality in sepsis.