J
Janine Reichenbach
Researcher at Boston Children's Hospital
Publications - 93
Citations - 7915
Janine Reichenbach is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Chronic granulomatous disease & Immunodeficiency. The author has an hindex of 39, co-authored 91 publications receiving 7029 citations. Previous affiliations of Janine Reichenbach include University of Zurich & French Institute of Health and Medical Research.
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Journal ArticleDOI
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
Shida Yousefi,Jeffrey A. Gold,Nicola Andina,James J. Lee,Ann M. Kelly,Evelyne Kozlowski,Inès Schmid,Alex Straumann,Janine Reichenbach,Gerald J. Gleich,Hans-Uwe Simon +10 more
TL;DR: It is shown that lipopolysaccharide from Gram-negative bacteria activates interleukin-5 (IL-5)- or interferon-γ–primed eosinophils to release mitochondrial DNA in a reactive oxygen species–dependent manner, but independent of eosInophil death, suggesting a previously undescribed mechanism of eOSinophil-mediated innate immune responses that might be crucial for maintaining the intestinal barrier function after inflammation-associated epithelial cell damage
Journal ArticleDOI
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
Luyan Liu,Satoshi Okada,Xiao-Fei Kong,Alexandra Y. Kreins,Sophie Cypowyj,Avinash Abhyankar,Julie Toubiana,Yuval Itan,Magali Audry,Patrick Nitschke,Cécile Masson,Beáta Tóth,Jérome Flatot,Mélanie Migaud,Maya Chrabieh,Tatiana Kochetkov,Alexandre Bolze,Alexandre Bolze,Alessandro Borghesi,Antoine Toulon,J. Hiller,Stefanie Eyerich,Kilian Eyerich,Vera Gulácsy,Ludmyla Chernyshova,Viktor P. Chernyshov,Anastasia Bondarenko,Rosa María Cortés Grimaldo,Lizbeth Blancas-Galicia,Ileana Maria Madrigal Beas,Joachim Roesler,Klaus Magdorf,Dan Engelhard,Caroline Thumerelle,Pierre-Régis Burgel,Miriam Hoernes,Barbara Drexel,Reinhard Seger,Theresia Kusuma,Annette Jansson,Julie Sawalle-Belohradsky,Bernd H. Belohradsky,Emmanuelle Jouanguy,Emmanuelle Jouanguy,Jacinta Bustamante,Mélanie Bué,Nathan Karin,Gizi Wildbaum,Christine Bodemer,Olivier Lortholary,Alain Fischer,Stéphane Blanche,Saleh Al-Muhsen,Janine Reichenbach,Masao Kobayashi,Francisco Espinosa Rosales,Carlos Torres Lozano,Sara Sebnem Kilic,Matías Oleastro,Amos Etzioni,Claudia Traidl-Hoffmann,Ellen D. Renner,Laurent Abel,Laurent Abel,Capucine Picard,Capucine Picard,László Maródi,Stéphanie Boisson-Dupuis,Stéphanie Boisson-Dupuis,Anne Puel,Jean-Laurent Casanova +70 more
TL;DR: Whole-exome sequencing reveals activating STAT1 mutations in some patients with autosomal dominant chronic mucocutaneous candidiasis disease.
Journal ArticleDOI
Restoration of NET formation by gene therapy in CGD controls aspergillosis
Matteo Bianchi,Abdul Hakkim,Volker Brinkmann,Ulrich Siler,Reinhard Seger,Arturo Zychlinsky,Janine Reichenbach +6 more
TL;DR: It is shown that reconstitution of NET formation by gene therapy in a patient with CGD restores neutrophil elimination of A nidulans conidia and hyphae and is associated with rapid cure of preexisting therapy refractory invasive pulmonary aspergillosis, underlining the role of functional NADPH oxidase in NET formation and antifungal activity.
Journal ArticleDOI
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype.
Julie Toubiana,Satoshi Okada,Satoshi Okada,Julia Hiller,Matías Oleastro,Macarena Lagos Gomez,Juan Carlos Aldave Becerra,Marie Ouachée-Chardin,Fanny Fouyssac,Katta M. Girisha,Amos Etzioni,Joris M. van Montfrans,Yildiz Camcioglu,Leigh Ann A. Kerns,Bernd H. Belohradsky,Stéphane Blanche,Stéphane Blanche,Aziz Bousfiha,Carlos Rodríguez-Gallego,Isabelle Meyts,Kai Kisand,Janine Reichenbach,Ellen D. Renner,Sergio D. Rosenzweig,Bodo Grimbacher,Frank L. van de Veerdonk,Claudia Traidl-Hoffmann,Capucine Picard,László Maródi,Tomohiro Morio,Masao Kobayashi,Desa Lilic,Joshua D. Milner,Steven M. Holland,Jean-Laurent Casanova,Anne Puel +35 more
TL;DR: Invasive infections, cerebral aneurysms, and cancers were the strongest predictors of poor outcome, and Circulating interleukin-17A-producing T-cell count was low for most (82%) but not all of the patients tested.
Journal ArticleDOI
Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency
Capucine Picard,Capucine Picard,Horst von Bernuth,Horst von Bernuth,Horst von Bernuth,Pegah Ghandil,Pegah Ghandil,Pegah Ghandil,Maya Chrabieh,Maya Chrabieh,Ofer Levy,Peter D. Arkwright,Douglas R. McDonald,Raif S. Geha,Hidetoshi Takada,Jens C. Krause,C. Buddy Creech,Cheng-Lung Ku,Cheng-Lung Ku,Stephan Ehl,László Maródi,Saleh Al-Muhsen,Saleh Al-Muhsen,Sami Al-Hajjar,Sami Al-Hajjar,Abdulaziz Al-Ghonaium,Abdulaziz Al-Ghonaium,Noorbibi K. Day-Good,Steven M. Holland,John I. Gallin,Helen Chapel,David P. Speert,Carlos Rodríguez-Gallego,Elena Colino,Ben Zion Garty,Chaim M. Roifman,Toshiro Hara,Hideto Yoshikawa,Shigeaki Nonoyama,Joseph B. Domachowske,Andrew C. Issekutz,Mimi L.K. Tang,Joanne Smart,Simona Eva Zitnik,Cyrille Hoarau,Dinakantha S. Kumararatne,Adrian J. Thrasher,E. Graham Davies,Claire Bethune,Nicolas Sirvent,Dominique De Ricaud,Yildiz Camcioglu,Júlia Vasconcelos,Margarida Guedes,Artur Bonito Vitor,Carlos Rodrigo,Francisco Almazán,Maria Méndez,Juan I. Aróstegui,Laia Alsina,Claudia Fortuny,Janine Reichenbach,James W. Verbsky,Xavier Bossuyt,Rainer Döffinger,Laurent Abel,Laurent Abel,Anne Puel,Anne Puel,Jean-Laurent Casanova +69 more
TL;DR: IRAK-4 and MyD88 deficiencies predispose patients to recurrent life-threatening bacterial diseases, such as invasive pneumococcal disease in particular, in infancy and early childhood, with weak signs of inflammation.