N
Nicola Andina
Researcher at University of Bern
Publications - 20
Citations - 1003
Nicola Andina is an academic researcher from University of Bern. The author has contributed to research in topics: Medicine & Immunology. The author has an hindex of 7, co-authored 12 publications receiving 842 citations. Previous affiliations of Nicola Andina include University Hospital of Basel.
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Journal ArticleDOI
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
Shida Yousefi,Jeffrey A. Gold,Nicola Andina,James J. Lee,Ann M. Kelly,Evelyne Kozlowski,Inès Schmid,Alex Straumann,Janine Reichenbach,Gerald J. Gleich,Hans-Uwe Simon +10 more
TL;DR: It is shown that lipopolysaccharide from Gram-negative bacteria activates interleukin-5 (IL-5)- or interferon-γ–primed eosinophils to release mitochondrial DNA in a reactive oxygen species–dependent manner, but independent of eosInophil death, suggesting a previously undescribed mechanism of eOSinophil-mediated innate immune responses that might be crucial for maintaining the intestinal barrier function after inflammation-associated epithelial cell damage
Journal ArticleDOI
Induction of Bim limits cytokine-mediated prolonged survival of neutrophils.
TL;DR: A functional role for Bim is demonstrated in the regulation of neutrophil apoptosis and it is suggested that GM-CSF and other neutrophils hematopoietins initiate a proapoptotic counterregulation that involves upregulation of Bim.
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Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
TL;DR: Pim-1, but not PI3K, plays a major role in IL-5-mediated antiapoptotic signaling in eosinophils, as identified by using specific protein transfer.
Journal ArticleDOI
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation
Vijaykumar Chennupati,Diogo F.T. Veiga,Kendle M. Maslowski,Nicola Andina,Aubry Tardivel,Aubry Tardivel,Eric Chi-Wang Yu,Martina Stilinovic,Cedric Simillion,Michel A. Duchosal,Manfredo Quadroni,Irene Roberts,Vijay G. Sankaran,Vijay G. Sankaran,H. Robson MacDonald,Nicolas Fasel,Anne Angelillo-Scherrer,Pascal Schneider,Trang Hoang,Ramanjaneyulu Allam +19 more
TL;DR: It is reported that RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1 and knockdown in human CD34+ progenitor cells decreased erystroid differentiation without affecting myelopOiesis.
Journal ArticleDOI
Increased cardiovascular comorbidities in patients with myelodysplastic syndromes and chronic myelomonocytic leukemia presenting with systemic inflammatory and autoimmune manifestations.
B. Kipfer,Thomas Daikeler,Stefan Kuchen,Mahmoud Hallal,Nicola Andina,Ramanjaneyulu Allam,Nicolas Bonadies +6 more
TL;DR: A significant association of SIAMs with cardiovascular comorbidities but without influence on progression or survival was identified, despite patient heterogeneity and small cohort size.