J
Jeffrey A. Jankowski
Researcher at University of North Carolina at Chapel Hill
Publications - 16
Citations - 2381
Jeffrey A. Jankowski is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Adrenal medulla & Chromaffin cell. The author has an hindex of 15, co-authored 16 publications receiving 2299 citations. Previous affiliations of Jeffrey A. Jankowski include University of Illinois at Urbana–Champaign & Nalco Holding Company.
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Journal ArticleDOI
Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells
R. M. Wightman,Jeffrey A. Jankowski,Robert T. Kennedy,Kirk T. Kawagoe,T.J. Schroeder,David J. Leszczyszyn,Joseph A. Near,E. J. Diliberto,O. H. Viveros +8 more
TL;DR: These measurements represent time-resolved observation of quantal secretion of catecholamine and provide direct evidence for the exocytotic hypothesis.
Journal ArticleDOI
Nicotinic receptor-mediated catecholamine secretion from individual chromaffin cells. Chemical evidence for exocytosis.
David J. Leszczyszyn,Jeffrey A. Jankowski,O H Viveros,E J Diliberto,Joseph A. Near,R. M. Wightman +5 more
TL;DR: Nicotinic receptor-mediated secretion of catecholamines from individual cultured bovine adrenal medullary chromaffin cells was measured and characterized with a voltametric microelectrode placed adjacent to the cells, consistent with direct chemical measurement of single exocytotic events.
Journal ArticleDOI
Analysis of diffusional broadening of vesicular packets of catecholamines released from biological cells during exocytosis
T.J. Schroeder,Jeffrey A. Jankowski,Kirk T. Kawagoe,R. Mark Wightman,Christine Lefrou,Christian Amatore +5 more
TL;DR: The broad range of spike widths observed experimentally and their individual shapes measured with 5-microns cell-electrode spacing are consistent with diffusion from point sources randomly distributed across a hemispherical surface, which can be described with the diffusion coefficient for catecholamines in free solution.
Journal ArticleDOI
Temporal characteristics of quantal secretion of catecholamines from adrenal medullary cells.
TL;DR: Results agree with the hypotheses that the chromaffin vesicle matrix normally exists in an aggregated state that can be dissociated by a chemical driving force at low extracellular pH.
Journal ArticleDOI
Etched carbon-fiber electrodes as amperometric detectors of catecholamine secretion from isolated biological cells
TL;DR: While the etched electrodes did not follow electrochemical theory as well as the glass-encased electrode, the etched electrode was found to be suitable for the amperometric measurement of the secretion of catecholamines from isolated bovine adrenal cells.