J
Jeffrey B. Arterburn
Researcher at New Mexico State University
Publications - 100
Citations - 7872
Jeffrey B. Arterburn is an academic researcher from New Mexico State University. The author has contributed to research in topics: Estrogen receptor & GPER. The author has an hindex of 34, co-authored 99 publications receiving 7292 citations. Previous affiliations of Jeffrey B. Arterburn include University of New Mexico.
Papers
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Journal ArticleDOI
A transmembrane intracellular estrogen receptor mediates rapid cell signaling.
TL;DR: It is found that of all G protein–coupled receptors characterized to date, GPR30 is uniquely localized to the endoplasmic reticulum, where it specifically binds estrogen and fluorescent estrogen derivatives.
Journal ArticleDOI
Virtual and biomolecular screening converge on a selective agonist for GPR30
Cristian Bologa,Chetana M. Revankar,Susan M. Young,Bruce S. Edwards,Jeffrey B. Arterburn,Alexander S. Kiselyov,Matthew A. Parker,Sergey E. Tkachenko,Nikolay P. Savchuck,Larry A. Sklar,Tudor I. Oprea,Eric R. Prossnitz +11 more
TL;DR: The identification of the first G PR30-specific agonist, G-1 (1), capable of activating GPR30 in a complex environment of classical and new estrogen receptors is described.
Journal ArticleDOI
Estrogen Signaling through the Transmembrane G Protein–Coupled Receptor GPR30
Eric R. Prossnitz,Jeffrey B. Arterburn,Jeffrey B. Arterburn,Harriet O. Smith,Tudor I. Oprea,Larry A. Sklar,Helen J. Hathaway +6 more
TL;DR: An overview of the evidence for the cellular and physiological actions of GPR30 in estrogen-dependent processes and the relationship of G PR30 with classical estrogen receptors is provided.
Journal ArticleDOI
In vivo effects of a GPR30 antagonist
Megan K. Dennis,Ritwik Burai,Chinnasamy Ramesh,Whitney K. Petrie,Sara N Alcon,Tapan K. Nayak,Cristian Bologa,Andrei Leitão,Eugen Brailoiu,Elena Deliu,Nae J. Dun,Larry A. Sklar,Helen J. Hathaway,Jeffrey B. Arterburn,Jeffrey B. Arterburn,Tudor I. Oprea,Eric R. Prossnitz +16 more
TL;DR: In vivo administration of G15 reveals that GPR30 contributes to both uterine and neurological responses initiated by estrogen, and the identification and characterization of a G-1 analog, G15, that binds to G PR30 with high affinity and acts as an antagonist of estrogen signaling through GPR28.
Journal ArticleDOI
GPR30: a G protein-coupled receptor for estrogen
TL;DR: The relationship between GPR30 and conventional estrogen receptor signaling is addressed and there is currently controversy over the ability of classical estrogen receptors to recapitulate G PR30-mediated signaling mechanisms and vice versa.