J
Jennifer D Williams
Researcher at St Thomas' Hospital
Publications - 9
Citations - 342
Jennifer D Williams is an academic researcher from St Thomas' Hospital. The author has contributed to research in topics: Biodistribution & Prostate cancer. The author has an hindex of 5, co-authored 9 publications receiving 295 citations. Previous affiliations of Jennifer D Williams include King's College London & University of London.
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Journal ArticleDOI
Comparison of (64)Cu-complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability.
Maggie S. Cooper,Michelle T. Ma,Kavitha Sunassee,Karen P. Shaw,Jennifer D Williams,Rowena L. Paul,Paul S. Donnelly,Philip J. Blower +7 more
TL;DR: While all the macrocyclic bifunctional chelators are suitable for molecular imaging using (64)Cu-labeled antibody conjugates, NOTA and sar-CO2H show significant advantages over the others in that they can be radiolabeled rapidly at room temperature, under dilute conditions, resulting in high specific activity.
labelled diabody of mAb J591 for SPECT imaging of prostate-specific membrane antigen (PSMA)
TL;DR: The presented diabody has favourable properties required to warrant its further development for antibody-based imaging of PSMA expression in prostate cancer, including PSMA-specific uptake, favourable pharmacokinetics compared to the parental antibody and efficient site-specific radiolabelling with 99mTc.
Journal ArticleDOI
Design and preclinical evaluation of a 99mTc-labelled diabody of mAb J591 for SPECT imaging of prostate-specific membrane antigen (PSMA).
Florian Kampmeier,Jennifer D Williams,John Maher,John Maher,Gregory E. D. Mullen,Philip J. Blower +5 more
TL;DR: In this paper, a diabody derived from mAb J591 was developed as a single photon emission computed tomography (SPECT) tracer with improved pharmacokinetics for the detection of PSMA expression in prostate cancer.
Journal ArticleDOI
Optimising the radiolabelling properties of technetium tricarbonyl and His-tagged proteins
Adam Badar,Adam Badar,Jennifer D Williams,Rafael Tm de Rosales,Richard Tavaré,Richard Tavaré,Florian Kampmeier,Philip J. Blower,Gregory E. D. Mullen +8 more
TL;DR: An optimised kit and protein radiolabelling conditions suitable for the reproducible, fast, efficient radiolABelling of proteins without the need for post-labelling purification are found.
Journal ArticleDOI
[Re(CO)3]+ labelling of a novel cysteine/hexahistidine tag: Insights into binding mode by liquid chromatography-mass spectrometry
TL;DR: It is confirmed that cysteine (Cys) was directly involved in the coordination of the rhenium tricarbonyl, and the superiority of the cysteines containing His-tag sequences for binding [Re(CO)(3)](+) was demonstrated.