Showing papers in "Journal of Inorganic Biochemistry in 2012"

TL;DR: The strategies that have led to the discovery of metal-based and organometallic ruthenium-based drugs NAMI-A and KP1019 are highlighted and their main biological/pharmacological characteristics and expectations for further development are reported.

TL;DR: The working hypotheses guiding the researchers in the field are reviewed while pointing out some more recent results that contradict some of the accepted paradigms in the hope of triggering some rethinking of the existing working hypotheses.

TL;DR: Analysis of studies from the own lab on model peptides raises an interesting hypothesis that various methionine/histidine/cysteine combinations provide organisms with dynamic, multifunctional domains on copper trafficking proteins that facilitate copper transfer under different extracellular, subcellular, and tissue-specific scenarios of pH, redox environment, and presence of other copper carriers or target proteins.

TL;DR: This paper reviews the available data for the inhibition of these enzymes with all anions except sulfonamides and their bioisosteres and designs novel types of inhibitors which may have clinical applications for the management of a variety of disorders in which CAs are involved.

TL;DR: Functional annotations of the remarkable variation of coordination environments in zinc proteomes need to consider how the primary coordination spheres interact with protein structure and dynamics, and the adaptation of coordination properties to the biological context in extracellular, cellular, or subcellular locations.

TL;DR: This work uses bioinformatics tools and databases that have been developed for the study of metalloproteins to gain insights into the functions of zinc in zinc enzymes, its coordination properties, and the usage of zinc enzymes in living organisms.

TL;DR: The ability of the Pt(IV) complexes to act as prodrugs for cisplatin are discussed and the effects of carbonate on the reduction/DNA-binding process are investigated.

TL;DR: The ATP-binding cassette (ABC) transporter proteins, multidrug resistance protein 1 (MRP1/ABCC1 and the related protein MRP2 (ABCC2), are thought to play an important role in arsenic detoxification through the cellular efflux of arsenic-GSH conjugates.

TL;DR: It is remarkable that all the complexes display cytotoxicity against human breast cancer cell lines and human cervical epidermoid carcinoma cell lines with potency higher than the currently used chemotherapeutic agent cisplatin and that 5 exhibits cytot toxicityHigher than the other complexes.

TL;DR: Cobalt(II) complexes with the non-steroidal anti-inflammatory drug naproxen in the presence of nitrogen-donor heterocyclic ligands (pyridine, 2,2'-bipyridine or 1,10-phenanthroline) have been synthesized and characterized with physicochemical and spectroscopic techniques.

TL;DR: In this paper, a 1:1 Pt-CTX conjugate was characterized by mass spectrometry and gel electrophoresis, and the cytotoxicity was lower in cell culture than that of cisplatin but greater than those of its Pt(IV) precursor and CTX in several cancer cell lines.

TL;DR: The possibility for an Al-superoxide complex to reduce Fe(III) to Fe(II), promoting oxidative damage through the Fenton reaction, is investigated using highly accurate ab initio methods and density functional theory in conjunction with solvation continuum methods to simulate bulk solvent effects.

TL;DR: It is proposed that ZitB functions as a constitutive, first-line defense against toxic zinc influx, while ZntA is up-regulated to efficiently lower the free zinc concentration.

TL;DR: UV study of the interaction of the quinolones and the complexes with calf-thymus DNA (CT DNA) has shown that they can bind to CT DNA with [Cu(II)(ofloxacin)(2)][(Cu(I)Cl(2))(2)] exhibiting the highest binding constant to CTDNA.

TL;DR: Copper(II) complexes with the first-generation quinolone antibacterial agent flumequine(Hflmq) in the presence or absence of the nitrogen donor heterocyclic ligands 2,2'-bipyridylamine(bipyam), 1,10-phenanthroline(phen) or pyridine(py) have been synthesized and characterized.

TL;DR: Biological studies, carried out in vitro against selected bacteria, fungi, and K562 leukaemia cell line, have shown that different substituted groups attached at the dithiocarbazate moieties and metals showed distinctive differences in the biological property.

TL;DR: Results strongly suggest that the cell intake route of both species is different supporting the Cu-complex's suitability as a candidate for further biological testing in fluoroquinolone-resistant microorganisms.

TL;DR: Molecular dynamics using the most abundant human cytochrome P450, CYP3A4, incorporated into a model POPC bilayer reveals the facile conservation of a substrateAccess channel directed into the membrane between the B-C loop and the beta domain, and the closure of the peripheral substrate access channel directed through the B -C loop.

TL;DR: Dietary Se oversupply may affect expression and activity of proteins involved in energy metabolism in major insulin target tissues, though this is probably not sufficient to induce diabetes.

TL;DR: Both 1 and 2 bind to BSA with a medium affinity through a static mode which is tentatively assigned binding to Trp134 in BSA, showing the involvement of a singlet oxygen-like entity and hydrogen peroxide in the cleavage process.

TL;DR: Five new heterocyclic gold carbene complexes were prepared, and in stark contrast to related metal-free 1-methyl-4,5-diarylimidazoles, the complexes 6 and 11 did not noticeably inhibit the polymerisation of tubulin to give microtubules.

TL;DR: Investigations revealed that the OCP thin films are deposited in the form of cauliflower-like aggregates and droplets, as well as crystal fragments, with a homogeneous distribution of magnesium and strontium on the surface of the coatings.

TL;DR: The intrinsic circular dichroism (CD) spectra show an unwinding and a conformational change of the DNA helix upon interaction of the ruthenium complex.

TL;DR: The potential of X-ray absorption spectroscopy to provide information and perspective which could aid in improving the accuracy of metalloprotein crystal structure solutions is reviewed.

TL;DR: The structural and functional commonalities of these metalloenzyme active sites are described, and the case is made for the formation and use of metal-metal bonds in each enzyme mentioned.

TL;DR: It is speculated that V10, which has a potential to be a potent effector for disease treatment, could have a role in treating Leishmania diseases.

TL;DR: In this tribute to Hans Freeman, investigations that have advanced the understanding of how inner-sphere and outer-spheres coordination affects biological Cu properties are reviewed.

TL;DR: Five mononuclear copper( II) and nickel(II) complexes of Schiff base ligands derived from 4-hydroxyphenethylamine and 2-phenylethylamine were synthesized and determined by single crystal X-ray analysis and presented the square planar coordination geometry at the metal center.

TL;DR: The results strongly suggest that CTR1 mediates cisplatin uptake in the cell lines studied and represents one of the determinants of cis platin resistance in A2780cis cell line.

TL;DR: The properties herein evaluated suggest that TM34 could be an anticancer agent of highly relevant therapeutic value.