Jennifer M. Capla

TL;DR: It is shown that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of S DF-1 in ischemic tissue in direct proportion to reduced oxygen tension.

TL;DR: It is suggested that type II diabetes may alter EPC biology in processes critical for new blood vessel growth and may identify a population at high risk for morbidity and mortality after vascular occlusive events.

TL;DR: It is concluded that BM-derived cells produce new blood vessels via localized recruitment, proliferation, and differentiation of circulating cells in a sequence of events markedly different from existing paradigms of angiogenesis.

TL;DR: It is suggested that diabetes causes defects in both the endothelial progenitor cell and peripheral tissue responses to hypoxia, and it is unlikely that endothelialprogenitor cell–based cellular therapies will be able to prevent diabetic complications.

TL;DR: Replacement of the donor graft vasculature by endothelial and endothelial progenitor cells from the recipient along preexisting channels is the predominant mechanism for skin graft revascularization.