J
Jennifer Major
Researcher at Cleveland Clinic Lerner Research Institute
Publications - 37
Citations - 3156
Jennifer Major is an academic researcher from Cleveland Clinic Lerner Research Institute. The author has contributed to research in topics: Kinesin & Chemokine. The author has an hindex of 23, co-authored 37 publications receiving 2984 citations. Previous affiliations of Jennifer Major include Mayo Clinic & Cleveland Clinic.
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Journal ArticleDOI
TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.
Vladimir Y. Toshchakov,Bryan W. Jones,Pin-Yu Perera,Karen Thomas,M. Joshua Cody,Shuling Zhang,Bryan R.G. Williams,Jennifer Major,Thomas A. Hamilton,Matthew J. Fenton,Stefanie N. Vogel +10 more
TL;DR: These findings provide the first mechanistic basis for differential patterns of gene expression activated by TLR4 and TLR2 agonists.
Journal ArticleDOI
Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.
Richard M. Ransohoff,Thomas A. Hamilton,Marie Tani,Mark H. Stoler,H E Shick,Jennifer Major,Melinda L. Estes,D M Thomas,Vincent K. Tuohy +8 more
TL;DR: In situ hybridizations showed, unexpectedly, that astrocytes were the major source of mRNAs encoding IP‐10 and JE/MCP‐1, which implicateAstrocyte‐derived cytokines as potential chemoattractants for inflammatory cells during EAE.
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Hypoxic induction of interleukin-8 gene expression in human endothelial cells.
M. Karakurum,Revati Shreeniwas,Jing Xian Chen,David J. Pinsky,Shirley ShiDu Yan,M. Anderson,K. Sunouchi,Jennifer Major,Thomas A. Hamilton,Keisuke Kuwabara +9 more
TL;DR: Hypoxia constitutes a stimulus for leukocyte chemotaxis and tissue leukostasis in mice exposed to hypoxia, and IL-8 gene induction was associated with the presence of increased binding activity in nuclear extracts from hypoxic ECs for the NF-kB site.
Journal Article
Regulation of Macrophage Chemokine Expression by Lipopolysaccharide In Vitro and In Vivo
Karen M. Kopydlowski,Cindy A. Salkowski,M. Joshua Cody,Nico van Rooijen,Jennifer Major,Thomas A. Hamilton,Stefanie N. Vogel +6 more
TL;DR: Findings indicate that selective regulation of chemokine expression in vivo may result from differential response of macrophages to pro- and antiinflammatory stimuli and to cell type-specific patterns of stimulus sensitivity, and suggest that individual chemokines are differentially regulated in response to LPS.
Journal ArticleDOI
Neutrophil chemoattractant genes KC and MIP‐2 are expressed in different cell populations at sites of surgical injury
TL;DR: It is demonstrated that distinct CXC chemokines show restricted expression in myeloid versus nonmyeloid cell types and that patterns of chemokine expression at sites of inflammation in vivo reflect the temporally ordered contribution of these distinct cell types.