V
Vincent K. Tuohy
Researcher at Cleveland Clinic Lerner College of Medicine
Publications - 119
Citations - 7304
Vincent K. Tuohy is an academic researcher from Cleveland Clinic Lerner College of Medicine. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & T cell. The author has an hindex of 42, co-authored 113 publications receiving 6982 citations. Previous affiliations of Vincent K. Tuohy include Cleveland Clinic Lerner Research Institute & Case Western Reserve University.
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Journal ArticleDOI
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian,Caini Liu,Justin Hartupee,Cengiz Z. Altuntas,Muhammet F. Gulen,Daniel Jane-wit,Jianhua Xiao,Yi Lu,Natalia Giltiay,Jinbo Liu,Tomasz Kordula,Qi-Wei Zhang,Bruce A. Vallance,Shadi Swaidani,Mark A. Aronica,Vincent K. Tuohy,Thomas A. Hamilton,Xiaoxia Li +17 more
TL;DR: The data show that Act1 is essential in IL-17-dependent signaling in autoimmune and inflammatory disease and was associated with much less inflammatory disease in vivo in both autoimmune encephalomyelitis and dextran sodium sulfate–induced colitis.
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Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis.
Richard M. Ransohoff,Thomas A. Hamilton,Marie Tani,Mark H. Stoler,H E Shick,Jennifer Major,Melinda L. Estes,D M Thomas,Vincent K. Tuohy +8 more
TL;DR: In situ hybridizations showed, unexpectedly, that astrocytes were the major source of mRNAs encoding IP‐10 and JE/MCP‐1, which implicateAstrocyte‐derived cytokines as potential chemoattractants for inflammatory cells during EAE.
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Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.
TL;DR: The role of T-cell tolerance to proteolipid protein (PLP) in susceptibility to experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, is analyzed and lack of tolerance to this epitope offers an explanation for the exquisite susceptibility of SJL/J mice to EAE.
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The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
Hui Xiao,Muhammet F. Gulen,Muhammet F. Gulen,Jinzhong Qin,Jinzhong Qin,Jianhong Yao,Katarzyna Bulek,Danielle D. Kish,Cengiz Z. Altuntas,David N Wald,Caixia Ma,Hang Zhou,Vincent K. Tuohy,Robert L. Fairchild,Carol A. de la Motte,Daniel J. Cua,Bruce A. Vallance,Xiaoxia Li +17 more
TL;DR: Gut epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora and reduced AOM+DSS-induced tumorigenesis.
Journal Article
Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.
TL;DR: It is proposed that chemokine expression links T-cell antigen recognition and activation to subsequent CNS inflammatory pathology in chronic relapsing EAE, and stringent regulation of multiple chemokines in vivo during a complex organ-specific autoimmune disease is demonstrated.