Jennifer Wymant

TL;DR: Eliminating exosomes from the cancer cell secretome, targeting Rab27a, abolished differentiation and lead to failure in stroma-assisted tumour growth in vivo, and exosomal TGFβ1 is therefore required for the formation of tumour-promoting stroma.

TL;DR: 3D printed microfluidic devices capable of operating at pressures in excess of 2000 kPa illustrate that leakage issues have also been resolved and it is demonstrated that previously reported limitations of transparency and fidelity have been overcome.

TL;DR: In this article, the cytotoxic effects of disulfiram in breast cancer cells, and its relationship with both intra and extracellular zinc were investigated, showing that the availability of extacellular zinc significantly influences disulfuram efficacy.

TL;DR: Strong evidence is obtained from spectroscopic and X-ray data analyses that the previously reported structure of similar analogues is not accurate, and a novel C3 hydroxy, cis-selective γ-lactone configuration of ring C in the azapodophyllotoxin scaffold is identified through an efficient stereoselective multicomponent reaction (MCR) involving fluorinated and non-fluorinated aldehydes.

TL;DR: Glycol chitosan nanogels may have potential as drug delivery vectors for targeting different intracellular compartments and the involvement of the actin cytoskeleton in nanogel uptake via macropinocytosis is suggested.