H
Howard Kynaston
Researcher at Cardiff University
Publications - 133
Citations - 8236
Howard Kynaston is an academic researcher from Cardiff University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 34, co-authored 120 publications receiving 6786 citations. Previous affiliations of Howard Kynaston include University Hospital of Wales & Cardiff and Vale University Health Board.
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Journal ArticleDOI
10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer
Freddie C. Hamdy,Jenny L Donovan,J. Athene Lane,Malcolm David Mason,Chris Metcalfe,Peter Holding,Michael Davis,Tim J Peters,Emma L Turner,Richard M. Martin,Jon Oxley,M.C. Robinson,John Staffurth,Eleanor I Walsh,Prasad Bollina,James W.F. Catto,Andrew Doble,Alan Doherty,David Gillatt,Roger Kockelbergh,Howard Kynaston,Alan Paul,Philip Powell,Stephen Prescott,Derek J. Rosario,Edward Rowe,David E. Neal,David E. Neal +27 more
TL;DR: At a median of 10 years, prostate-cancer-specific mortality was low irrespective of the treatment assigned, with no significant difference among treatments.
Journal ArticleDOI
Patient-Reported Outcomes after Monitoring, Surgery, or Radiotherapy for Prostate Cancer
Jenny L Donovan,Freddie C. Hamdy,J A Lane,Malcolm David Mason,Chris Metcalfe,Eleanor I Walsh,Jane M Blazeby,Tim J Peters,Peter Holding,Bonnington S,T Lennon,Lynne Bradshaw,Cooper D,Phillipa Herbert,Howson J,Arwyn Tomos Jones,Norma Lyons,Salter E,Pauline Thompson,Sarah Tidball,Jan Blaikie,Catherine Gray,Prasad Bollina,James W.F. Catto,Andrew Doble,Alan Doherty,David Gillatt,Roger Kockelbergh,Howard Kynaston,Alan Paul,Philip Powell,Stephen Prescott,Derek J. Rosario,Edward Rowe,Michael Davis,Emma L Turner,Richard M. Martin,David E. Neal,David E. Neal +38 more
TL;DR: In this analysis of patient-reported outcomes after treatment for localized prostate cancer, patterns of severity, recovery, and decline in urinary, bowel, and sexual function and associated quality of life differed among the three groups.
Journal ArticleDOI
The effects of induced hypogonadism on arterial stiffness, body composition, and metabolic parameters in males with prostate cancer
J. C. Smith,S. Bennett,L. M. Evans,Howard Kynaston,Mahesh K. B. Parmar,Malcolm David Mason,J.R. Cockcroft,Maurice F. Scanlon,Jeffrey S. Davies +8 more
TL;DR: The data indicate that induced hypogonadism in males with prostate cancer results in a rise in the augmentation of central arterial pressure, suggesting large artery stiffening.
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An international field study of the EORTC QLQ-PR25: A questionnaire for assessing the health-related quality of life of patients with prostate cancer
George van Andel,Andrew Bottomley,Sophie D. Fosså,Fabio Efficace,Corneel Coens,Stephane Guerif,Howard Kynaston,Paolo Gontero,George N. Thalmann,Atif Akdas,Sven D’Haese,Neil K. Aaronson +11 more
TL;DR: The QLQ-PR25 demonstrates acceptable psychometric properties and clinical validity, and some caution should be used in interpreting the bowel function and side-effects of hormonal therapy scales; results can be reported at the individual item and scale level.
Journal ArticleDOI
Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes.
Jason P. Webber,Lisa Kate Spary,Andrew James Sanders,Ruhena Chowdhury,Wen Jiang,Robert Steadman,Jennifer Wymant,Arwyn Tomos Jones,Howard Kynaston,Malcolm David Mason,Zsuzsanna Tabi,Aled Clayton +11 more
TL;DR: Eliminating exosomes from the cancer cell secretome, targeting Rab27a, abolished differentiation and lead to failure in stroma-assisted tumour growth in vivo, and exosomal TGFβ1 is therefore required for the formation of tumour-promoting stroma.