Jenny E. Hinshaw

TL;DR: Data indicate the mitochondrial division dynamin directly regulates mitochondrial outer membrane permeabilization independent of Drp1-mediated division, raising the interesting possibility that mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.

TL;DR: It is shown that dynamin spontaneously self-assembles into rings and stacks of interconnected rings, comparable in dimension to the 'collars' observed at the necks of invaginated coated pits that accumulate at synaptic terminals in shibire flies.

TL;DR: Purified dynamin readily self-assembles into rings or spirals, which supports the hypothesis that dynamin wraps around the necks of budding vesicles where it plays a key role in membrane fission.

TL;DR: Data presented here demonstrate that purified recombinant dynamin binds to a lipid bilayer in a regular pattern to form helical tubes that constrict and vesiculate upon GTP addition, suggesting that dynamin alone is sufficient for the formation of constricted necks of coated pits and supports the hypothesis that dynamIn is the force-generating molecule responsible for membrane fission.

TL;DR: Evidence is provided that Dnm1 likely functions through self-assembly to drive the membrane constriction event that is associated with mitochondrial division and extended spirals formed, which possessed diameters greater than those of dynamin-1 spirals but whose sizes were equal to those of mitochondrial constriction sites in vivo.