M
Mark J. Kurth
Researcher at University of California, Davis
Publications - 432
Citations - 11210
Mark J. Kurth is an academic researcher from University of California, Davis. The author has contributed to research in topics: Cycloaddition & Nitrile. The author has an hindex of 49, co-authored 430 publications receiving 10561 citations. Previous affiliations of Mark J. Kurth include University of California & American University of Beirut.
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Journal ArticleDOI
Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.
Ann Cassidy-Stone,Jerry E. Chipuk,Elena Ingerman,Cheng Song,Choong Yoo,Tomomi Kuwana,Mark J. Kurth,Jared T. Shaw,Jenny E. Hinshaw,Douglas R. Green,Jodi Nunnari +10 more
TL;DR: Data indicate the mitochondrial division dynamin directly regulates mitochondrial outer membrane permeabilization independent of Drp1-mediated division, raising the interesting possibility that mdivi-1 represents a class of therapeutics for stroke, myocardial infarction, and neurodegenerative diseases.
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Mechanism-based corrector combination restores ΔF508-CFTR folding and function
Tsukasa Okiyoneda,Guido Veit,Johanna F. Dekkers,Miklós Bagdány,Naoto Soya,Haijin Xu,Ariel Roldan,Alan S. Verkman,Mark J. Kurth,Ágnes Simon,Tamás Hegedus,Jeffrey M. Beekman,Gergely L. Lukacs +12 more
TL;DR: The molecular targets of available correctors are elucidated: class I stabilizes the NBD1-MSD1 and N BD1- MSD2 interfaces, and class II targets NBD2, which stabilizes human ΔF508-NBD1.
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Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium*
Carlo Selmi,Carlo Selmi,David L. Balkwill,Pietro Invernizzi,Aftab A. Ansari,Ross L. Coppel,Mauro Podda,Patrick S.C. Leung,Thomas P. Kenny,Judy Van de Water,Michael H. Nantz,Mark J. Kurth,M. Eric Gershwin +12 more
TL;DR: It is proposed that N. aromaticivorans is a candidate for the induction of PBC, based on protein homology, capacity to metabolize xenobiotics as well as modulate estrogens, its presence in feces, and specific immunologic response.
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"Analogous" Organic Synthesis of Small-Compound Libraries: Validation of Combinatorial Chemistry in Small-Molecule Synthesis
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Novel CFTR Chloride Channel Activators Identified by Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds
Luis J. V. Galietta,Mark F. Springsteel,Masahiro Eda,Edmund J. Niedzinski,Kolbot By,Makhluf J. Haddadin,Mark J. Kurth,Michael H. Nantz,Alan S. Verkman +8 more
TL;DR: The results establish an efficient screening procedure to identify CFTR activators and inhibitors and have identified 7,8-benzoflavones and pyrazolo derivatives as novel classes of CFTR Activators.