Showing papers by "Jenny Karlsson published in 2000"
TL;DR: Different approaches that reduce cell death and increase survival of grafted neurons, typically by a factor of 2–4 are reviewed; changes in transplantation procedure such as improved media and implantation technique can be beneficial, and calcium channel antagonists such as nimodipine and flunarizine improve nigral graft survival.
312 citations
TL;DR: Combining treatments that counteract oxidative stress and caspase activation is a valuable strategy to enhance nigral graft survival that should be considered for clinical application.
87 citations
TL;DR: It is demonstrated that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons.
Abstract: Hypothermia can reduce neuronal death caused by ischemia and traumatic brain injury. We therefore investigated whether mild hypothermia in rats receiving a transplant of embryonic mesencephalic rat tissue increases survival of the implanted dopaminergic neurons. Mild hypothermia (32-33°C) during graft implantation and for the following 90 min significantly increased the survival of transplanted dopaminergic neurons to 171% of control values in normothermic (37°C) rats. This demonstrates that treatment of the graft recipient for a relatively short period during and after surgery has a favorable effect on the survival of grafted dopaminergic neurons. These findings may be of importance for clinical neural transplantation trials which are in need of procedures that improve transplant survival. (C) 2000 Lippincott Williams and Wilkins. (Less)
24 citations
TL;DR: The effects of pretreatment of the graft tissue with the N-methyl-D-aspartate (NMDA) receptor antagonist (+)dizocilpine hydrogen maleate and lipid peroxidation inhibitor lazaroid U-83836E are investigated, suggesting that NMDA-related excitotoxicity or oxidative stress may not be primary mediators of cell death in striatal grafts.
5 citations