Åsa Petersén

TL;DR: Telomeric dysfunction may trigger chromosomal fragmentation through persistent bridge-breakage events in pancreatic carcinomas and osteosarcomas, leading to a continuous reorganization of the tumor genome.

TL;DR: Different approaches that reduce cell death and increase survival of grafted neurons, typically by a factor of 2–4 are reviewed; changes in transplantation procedure such as improved media and implantation technique can be beneficial, and calcium channel antagonists such as nimodipine and flunarizine improve nigral graft survival.

TL;DR: The results show that the loss of orexin is a novel and potentially very important pathology in HD and could be used as a biomarker reflecting neurodegeneration.

TL;DR: It is proposed that the presence of exon 1 of the mutant HD gene induces profound changes in striatal neurons that render these cells resistant to excessive NMDA receptor activation.

TL;DR: Plasma changes with HD progression are revealed and identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.