J
Jenny Y. Wu
Researcher at Brigham and Women's Hospital
Publications - 3
Citations - 1344
Jenny Y. Wu is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Telomere & Keratinocyte. The author has an hindex of 2, co-authored 3 publications receiving 1216 citations.
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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mark A. Dickson,William C. Hahn,William C. Hahn,Yasushi Ino,Vincent Ronfard,Jenny Y. Wu,Robert A. Weinberg,David N. Louis,Frederick P. Li,James G. Rheinwald +9 more
TL;DR: Keratinocyte replicative potential is limited by a p16INK4a-dependent mechanism, the activation of which can occur independent of telomere length, and abrogation of this mechanism together with telomerase expression immortalizes keratinocytes without affecting other major growth control or differentiation systems.
Journal ArticleDOI
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
James G. Rheinwald,William C. Hahn,William C. Hahn,Matthew R. Ramsey,Jenny Y. Wu,Zongyou Guo,Hensin Tsao,Michele De Luca,Caterina Catricalà,Kathleen M. O'Toole +9 more
TL;DR: It is confirmed that keratinocytes undergo p16-related senescence during growth in culture, whether in the fibroblast feeder cell system or in the specialized K-sfm medium formulation, and that this mechanism can act as a barrier to immortalization following hTERT expression.