F
Frederick P. Li
Researcher at Harvard University
Publications - 160
Citations - 18633
Frederick P. Li is an academic researcher from Harvard University. The author has contributed to research in topics: Cancer & Wilms' tumor. The author has an hindex of 58, co-authored 160 publications receiving 18140 citations. Previous affiliations of Frederick P. Li include University of Colorado Denver & National Institutes of Health.
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Journal ArticleDOI
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
David Malkin,Frederick P. Li,Frederick P. Li,Louise C. Strong,Joseph F. Fraumeni,Camille E. Nelson,Camille E. Nelson,David H. Kim,Jayne Kassel,Magdalena A. Gryka,Farideh Z. Bischoff,Michael A. Tainsky,Stephen H. Friend +12 more
TL;DR: Germ line p53 mutations have been detected in all five LFS families analyzed and can now be examined in additional families with LFS, and in other cancer patients and families with clinical features that might be attributed to the mutation.
Journal ArticleDOI
Soft-Tissue Sarcomas, Breast Cancer, and Other Neoplasms: A Familial Syndrome?
TL;DR: A new "familial" syndrome of neoplastic diseases in which heredity or oncogenic agents, or both, may have a causal role is suggested.
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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mark A. Dickson,William C. Hahn,William C. Hahn,Yasushi Ino,Vincent Ronfard,Jenny Y. Wu,Robert A. Weinberg,David N. Louis,Frederick P. Li,James G. Rheinwald +9 more
TL;DR: Keratinocyte replicative potential is limited by a p16INK4a-dependent mechanism, the activation of which can occur independent of telomere length, and abrogation of this mechanism together with telomerase expression immortalizes keratinocytes without affecting other major growth control or differentiation systems.
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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
Daphne W. Bell,Jennifer M. Varley,Tara E. Szydlo,Deborah H. Kang,Doke C.R. Wahrer,Kristen E. Shannon,Marcie L. Lubratovich,Sigitas Verselis,Kurt J. Isselbacher,Joseph F. Fraumeni,Jillian M. Birch,Frederick P. Li,Judy Garber,Daniel A. Haber +13 more
TL;DR: HCHK2 is a tumor suppressor gene conferring predisposition to sarcoma, breast cancer, and brain tumors, and the central role of p53 inactivation in human cancer and the well-defined G2 checkpoint in yeast is provided.
Journal ArticleDOI
Bone sarcomas linked to radiotherapy and chemotherapy in children.
Margaret A. Tucker,Giulio J. D'Angio,Jr Jd Boice,Louise C. Strong,Frederick P. Li,Marilyn Stovall,B. J. Stone,Daniel M. Green,F Lombardi,W Newton +9 more
TL;DR: It is concluded that both radiotherapy and chemotherapy with alkylating agents for childhood cancer increase the subsequent risk of bone cancer.