J
Jenny Z. Zheng
Researcher at Johns Hopkins University School of Medicine
Publications - 2
Citations - 661
Jenny Z. Zheng is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Insulin receptor & Fusion protein. The author has an hindex of 2, co-authored 2 publications receiving 618 citations.
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Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α MODULATION OF TRANSCRIPTIONAL ACTIVITY BY OXYGEN TENSION
TL;DR: It is demonstrated that HIF-1α contains two transactivation domains located between amino acids 531 and 826, which indicate that increased transcriptional activity mediated by Hif-1 in hypoxic cells results from both increased H IF-1 α protein levels and increased activity of HIF -1α trans activation domains.
Journal ArticleDOI
Integrin α1-null mice exhibit improved fatty liver when fed a high fat diet despite severe hepatic insulin resistance
Ashley S. Williams,Li Kang,Jenny Z. Zheng,Carrie A. Grueter,Deanna P. Bracy,Freyja D. James,Ambra Pozzi,David H. Wasserman +7 more
TL;DR: It is shown that expression of the α1 subunit is increased in hepatocytes isolated from high fat (HF)-fed mice, establishing a role for integrin signaling in facilitating hepatic insulin action while promoting lipid accumulation in mice challenged with a HF diet.