抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Evolutionary psychology is one of many biologically informed approaches to the study of human behavior. Along with cognitive psychologists, evolutionary psychologists propose that much, if not all, of our behavior can be explained by appeal to internal psychological mechanisms. What distinguishes evolutionary psychologists from many cognitive psychologists is the proposal that the relevant internal mechanisms are adaptations—products of natural selection—that helped our ancestors get around the world, survive and reproduce. To understand the central claims of evolutionary psychology we require an understanding of some key concepts in evolutionary biology, cognitive psychology, philosophy of science and philosophy of mind. Philosophers are interested in evolutionary psychology for a number of reasons. For philosophers of science —mostly philosophers of biology—evolutionary psychology provides a critical target. There is a broad consensus among philosophers of science that evolutionary psychology is a deeply flawed enterprise. For philosophers of mind and cognitive science evolutionary psychology has been a source of empirical hypotheses about cognitive architecture and specific components of that architecture. Philosophers of mind are also critical of evolutionary psychology but their criticisms are not as all-encompassing as those presented by philosophers of biology. Evolutionary psychology is also invoked by philosophers interested in moral psychology both as a source of empirical hypotheses and as a critical target.

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Stanford Encyclopedia of Philosophy

Modified gravity theories have received increased attention lately due to combined motivation coming from high-energy physics, cosmology, and astrophysics. Among numerous alternatives to Einstein's theory of gravity, theories that include higher-order curvature invariants, and specifically the particular class of $f(R)$ theories, have a long history. In the last five years there has been a new stimulus for their study, leading to a number of interesting results. Here $f(R)$ theories of gravity are reviewed in an attempt to comprehensively present their most important aspects and cover the largest possible portion of the relevant literature. All known formalisms are presented---metric, Palatini, and metric affine---and the following topics are discussed: motivation; actions, field equations, and theoretical aspects; equivalence with other theories; cosmological aspects and constraints; viability criteria; and astrophysical applications.

f ( R ) theories of gravity

Modified Gravity and Cosmology

The status of experimental tests of general relativity and of theoretical frameworks for analyzing them is reviewed and updated. Einstein’s equivalence principle (EEP) is well supported by experiments such as the Eotvos experiment, tests of local Lorentz invariance and clock experiments. Ongoing tests of EEP and of the inverse square law are searching for new interactions arising from unification or quantum gravity. Tests of general relativity at the post-Newtonian level have reached high precision, including the light deflection, the Shapiro time delay, the perihelion advance of Mercury, the Nordtvedt effect in lunar motion, and frame-dragging. Gravitational wave damping has been detected in an amount that agrees with general relativity to better than half a percent using the Hulse-Taylor binary pulsar, and a growing family of other binary pulsar systems is yielding new tests, especially of strong-field effects. Current and future tests of relativity will center on strong gravity and gravitational waves.

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The Confrontation Between General Relativity and Experiment

Mycobacterium smegmatis porin A (MspA) forms an octameric channel and represents the founding member of a new family of pore proteins. Control of subunit stoichiometry is important to tailor MspA for nanotechnological applications. In this study, two MspA monomers were connected by linkers ranging from 17 to 62 amino acids in length. The oligomeric pore proteins were purified from M. smegmatis and were shown to form functional channels in lipid bilayer experiments. These results indicated that the peptide linkers did not prohibit correct folding and localization of MspA. However, expression levels were reduced by 10-fold compared to wild-type MspA. MspA is ideal for nanopore sequencing due to its unique pore geometry and its robustness. To assess the usefulness of MspA made from dimeric subunits for DNA sequencing, we linked two M1-MspA monomers, whose constriction zones were modified to enable DNA translocation. Lipid bilayer experiments demonstrated that this construct also formed functional channels. Voltage gating of MspA pores made from M1 monomers and M1-M1 dimers was identical indicating similar structural and dynamic channel properties. Glucose uptake in M. smegmatis cells lacking porins was restored by expressing the dimeric mspA M1 gene indicating correct folding and localization of M1-M1 pores in their native membrane. Single-stranded DNA hairpins produced identical ionic current blockades in pores made from monomers and subunit dimers demonstrating that M1-M1 pores are suitable for DNA sequencing. This study provides the proof of principle that production of single-chain MspA pores in M. smegmatis is feasible and paves the way for generating MspA pores with altered stoichiometries. Subunit dimers enable better control of the chemical and physical properties of the constriction zone of MspA. This approach will be valuable both in understanding transport across the outer membrane in mycobacteria and in tailoring MspA for nanopore sequencing of DNA.

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MspA Nanopores from Subunit Dimers

We present an analysis of Brownian force noise from residual gas damping of reference test masses as a fundamental sensitivity limit in small force experiments. The resulting acceleration noise increases significantly when the distance of the test mass to the surrounding experimental apparatus is smaller than the dimension of the test mass itself. For the Advanced LIGO interferometric gravitational wave observatory, where the relevant test mass is a suspended 340 mm diameter cylindrical end mirror, the force noise power is increased by roughly a factor 40 by the presence of a similarly shaped reaction mass at a nominal separation of 5 mm. The force noise, of order $20\text{ }\text{ }\mathrm{fN}/{\mathrm{Hz}}^{1/2}$ for $2\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}\text{ }\text{ }\mathrm{Pa}$ of residual ${\mathrm{H}}_{2}$ gas, rivals quantum optical fluctuations as the dominant noise source between 10 and 30 Hz. We present here a numerical and analytical analysis for the gas damping force noise for Advanced LIGO, backed up by experimental evidence from several recent measurements. Finally, we discuss the impact of residual gas damping on the gravitational wave sensitivity and possible mitigation strategies.

Brownian force noise from molecular collisions and the sensitivity of advanced gravitational wave observatories

Nanopores are emerging as new single-molecule tools in the study of enzymes. Based on the progress in nanopore sequencing of DNA, a tool called Single-molecule Picometer Resolution Nanopore Tweezers (SPRNT) was developed to measure the movement of enzymes along DNA in real time. In this new method, an enzyme is loaded onto a DNA (or RNA) molecule. A single-stranded DNA end of this complex is drawn into a nanopore by an electrostatic potential that is applied across the pore. The single-stranded DNA passes through the pore's constriction until the enzyme comes into contact with the pore. Further progression of the DNA through the pore is then controlled by the enzyme. An ion current that flows through the pore's constriction is modulated by the DNA in the constriction. Analysis of ion current changes reveals the advance of the DNA with high spatiotemporal precision, thereby providing a real-time record of the enzyme's activity. Using an engineered version of the protein nanopore MspA, SPRNT has spatial resolution as small as 40 pm at millisecond timescales, while simultaneously providing the DNA's sequence within the enzyme. In this chapter, SPRNT is introduced and its extraordinary potential is exemplified using the helicase Hel308. Two distinct substates are observed for each one-nucleotide advance; one of these about half-nucleotide long steps is ATP dependent and the other is ATP independent. The spatiotemporal resolution of this low-cost single-molecule technique lifts the study of enzymes to a new level of precision, enabling exploration of hitherto unobservable enzyme dynamics in real time.

Subangstrom Measurements of Enzyme Function Using a Biological Nanopore, SPRNT.

We have deduced compound nuclear isospin mixing in $^{28}\mathrm{Si}^{\mathrm{*}}$ and $^{26}\mathrm{Al}^{\mathrm{*}}$ at excitation energies between 33 and 65 MeV. The \ensuremath{\gamma}-ray yield from the decay of giant dipole resonances built on excited states is found to be suppressed, implying that isospin mixing is small. By comparison with data from the literature at lower excitation energy, we conclude that isospin is a better symmetry in these compound nuclei at high excitation energy.

Restoration of isospin symmetry in highly excited compound nuclei

The extraordinary sensitivity of the torsion balance has made it a valuable tool to test symmetries in nature and to search for new weak macroscopic forces. Most torsion balance experiments employ unpolarized test bodies either of different composition to test the universality of free fall or of special geometry to test for violations of the 1/r2 law of gravity.1 There are several motivations, however, to perform similar torsion balance measurements with spin polarized test bodies: to help elucidate the role of spin in gravitation, to search for new forces mediated by pseudoscalar bosons, and to perform a precise test of Lorentz (rotational) and CPT invariance. We have constructed an electron spin polarized test body and have completed a first round of measurements with this test body mounted on our EotWash II torsion balance2 In this paper, we present our results and interpret them as new limits on the strength and range of macroscopic spin coupled interactions and as a new limit on Lorentz and CPT invariance violation. Moody and Wilczek3 have shown that the exchange of a mixed parity boson (such as the axion, a proposed 0– particle with a small admixture of 0+) leads to a CP-violating potential between two point particles of the form:

Jens H. Gundlach

Papers

MspA Nanopores from Subunit Dimers

Brownian force noise from molecular collisions and the sensitivity of advanced gravitational wave observatories

Subangstrom Measurements of Enzyme Function Using a Biological Nanopore, SPRNT.

Restoration of isospin symmetry in highly excited compound nuclei

Torsion Balance Test of Spin Coupled Forces