J
Jens Kockskämper
Researcher at University of Marburg
Publications - 38
Citations - 1316
Jens Kockskämper is an academic researcher from University of Marburg. The author has contributed to research in topics: Heart failure & Ryanodine receptor 2. The author has an hindex of 18, co-authored 35 publications receiving 1152 citations. Previous affiliations of Jens Kockskämper include Medical University of Graz & University of Graz.
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Journal ArticleDOI
Long-Term Cardiac-Targeted RNA Interference for the Treatment of Heart Failure Restores Cardiac Function and Reduces Pathological Hypertrophy
Lennart Suckau,Henry Fechner,Elie R. Chemaly,Stefanie Krohn,Lahouaria Hadri,Jens Kockskämper,Dirk Westermann,Egbert Bisping,Hung Q. Ly,Xiaomin Wang,Yoshiaki Kawase,Jiqiu Chen,Lifan Liang,Isaac Sipo,Roland Vetter,Stefan Weger,Jens Kurreck,Volker A. Erdmann,Carsten Tschöpe,Burkert Pieske,Djamel Lebeche,Heinz-Peter Schultheiss,Roger J. Hajjar,Wolfgang Poller +23 more
TL;DR: Targeted RNAi for the treatment of heart failure is demonstrated in a rat model of transaortic banding by RNAi targeting of phospholamban, a key regulator of cardiac Ca2+ homeostasis and shows for the first time the high efficacy of an RNAi therapeutic strategy in a cardiac disease.
Journal ArticleDOI
Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes
Jens Kockskämper,Aleksey V. Zima,H. Llewelyn Roderick,H. Llewelyn Roderick,Burkert Pieske,Lothar A. Blatter,Martin D. Bootman +6 more
TL;DR: Intriguingly, expression of both IP(3)Rs and membrane receptors that couple to PLC/IP(2) signaling is altered in cardiac disease such as atrial fibrillation or heart failure, suggesting the involvement of IP( 3) signaling in the pathology of these diseases.
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Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation
Simon Sedej,Frank R. Heinzel,Stefanie Walther,Nataliya Dybkova,Paulina Wakula,Jan Groborz,Phillip Gronau,Lars S. Maier,Marc A. Vos,F. Anthony Lai,Carlo Napolitano,Silvia G. Priori,Jens Kockskämper,Burkert Pieske +13 more
TL;DR: In this article, a human RyR2-mediated sarcoplasmic reticulum (SR) Ca2+ release in response to SR Ca 2+ overload during β-adrenergic stimulation was investigated in the absence and presence of 1 µmol/L JTV-519 (RyR2 stabilizer) followed by 100 µmol /L ouabain intervention to increase cytosolic [Na+] and SR Ca2 + load.
Journal ArticleDOI
The slow force response to stretch in atrial and ventricular myocardium from human heart: functional relevance and subcellular mechanisms.
Jens Kockskämper,Dirk von Lewinski,Mounir Khafaga,Andreas Elgner,Michael Grimm,Thomas Eschenhagen,Philip A. Gottlieb,Frederick Sachs,Burkert Pieske +8 more
TL;DR: In human heart both atrial and ventricular myocardium exhibit a stretch-dependent SFR that might serve to adjust cardiac output to increased workload.
Journal ArticleDOI
Early Remodeling of Perinuclear Ca2+ Stores and Nucleoplasmic Ca2+ Signaling During the Development of Hypertrophy and Heart Failure
Senka Ljubojevic,Snjezana Radulovic,Gerd Leitinger,Simon Sedej,Michael Sacherer,Michael Holzer,Claudia Winkler,Elisabeth Pritz,Tobias Mittler,Albrecht Schmidt,Michael Sereinigg,Paulina Wakula,Spyros Zissimopoulos,Egbert Bisping,Heiner Post,Gunther Marsche,Julie Bossuyt,Donald M. Bers,Jens Kockskämper,Burkert Pieske +19 more
TL;DR: In this article, structural and functional changes of the nuclear envelope and nuclear Ca2+ handling in cardiomyocytes as remodeling progresses were found to contribute to the development and progression of heart failure.