The last decade has witnessed significant advances in energy harvesting technologies as a possible alternative to provide a continuous power supply for small, low-power devices in applications, such as wireless sensing, data transmission, actuation, and medical implants. Piezoelectric energy harvesting (PEH) has been a salient topic in the literature and has attracted widespread attention from researchers due to its advantages of simple architecture, high power density, and good scalability. This paper presents a comprehensive review on the state-of-the-art of piezoelectric energy harvesting. Various key aspects to improve the overall performance of a PEH device are discussed, including basic fundamentals and configurations, materials and fabrication, performance enhancement mechanisms, applications, and future outlooks.

A comprehensive review on piezoelectric energy harvesting technology: Materials, mechanisms, and applications

Implantable neuroprostheses are engineered systems designed to restore or substitute function for individuals with neurological deficits or disabilities. These systems involve at least one uni- or bidirectional interface between a living neural tissue and a synthetic structure, through which information in the form of electrons, ions or photons flows. Despite a few notable exceptions, the clinical dissemination of implantable neuroprostheses remains limited, because many implants display inconsistent long-term stability and performance, and are ultimately rejected by the body. Intensive research is currently being conducted to untangle the complex interplay of failure mechanisms. In this Review, we emphasize the importance of minimizing the physical and mechanical mismatch between neural tissues and implantable interfaces. We explore possible materials solutions to design and manufacture neurointegrated prostheses, and outline their immense therapeutic potential. Implantable neuroprostheses communicate with the nervous system to provide diagnosis or therapy to the injured body. In this review, we discuss materials-based approaches to overcome the physical and mechanical mismatch at the tissue–implant interface and to design long-term neurointegrated prostheses.

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Materials and technologies for soft implantable neuroprostheses

Soft electronics are intensively studied as the integration of electronics with dynamic nonplanar surfaces has become necessary. Here, a discussion of the strategies in materials innovation and structural design to build soft electronic devices and systems is provided. For each strategy, the presentation focuses on the fundamental materials science and mechanics, and example device applications are highlighted where possible. Finally, perspectives on the key challenges and future directions of this field are presented.

Materials and Structures toward Soft Electronics.

Highly sensitive wearable sensors that can be conformably attached to human skin or integrated with textiles to monitor the physiological parameters of human body or the surrounding environment have garnered tremendous interest. Owing to the large surface area and outstanding material properties, nanomaterials are promising building blocks for wearable sensors. Recent advances in the nanomaterial-enabled wearable sensors including temperature, electrophysiological, strain, tactile, electrochemical, and environmental sensors are presented in this review. Integration of multiple sensors for multimodal sensing and integration with other components into wearable systems are summarized. Representative applications of nanomaterial-enabled wearable sensors for healthcare, including continuous health monitoring, daily and sports activity tracking, and multifunctional electronic skin are highlighted. Finally, challenges, opportunities, and future perspectives in the field of nanomaterial-enabled wearable sensors are discussed.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.201700889%4010.1002/%28ISSN%292192-2659.Diagnostic-Devices-for-Healthcare

Nanomaterial-Enabled Wearable Sensors for Healthcare.

Методы подавления шумов и помех в электронных системах. (Noise reduction techniques in electronic systems)

The development of various flexible and stretchable materials has attracted interest for promising applications in biomedical engineering and electronics industries. This interest in wearable electronics, stretchable circuits, and flexible displays has created a demand for stable, easily manufactured, and cheap materials. However, the construction of flexible and elastic electronics, on which commercial electronic components can be mounted through simple and cost-effective processing, remains challenging. We have developed a nanocomposite of carbon nanotubes (CNTs) and polydimethylsiloxane (PDMS) elastomer. To achieve uniform distributions of CNTs within the polymer, an optimized dispersion process was developed using isopropyl alcohol (IPA) and methyl-terminated PDMS in combination with ultrasonication. After vaporizing the IPA, various shapes and sizes can be easily created with the nanocomposite, depending on the mold. The material provides high flexibility, elasticity, and electrical conductivity without requiring a sandwich structure. It is also biocompatible and mechanically stable, as demonstrated by cytotoxicity assays and cyclic strain tests (over 10,000 times). We demonstrate the potential for the healthcare field through strain sensor, flexible electric circuits, and biopotential measurements such as EEG, ECG, and EMG. This simple and cost-effective fabrication method for CNT/PDMS composites provides a promising process and material for various applications of wearable electronics.

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Simple and cost-effective method of highly conductive and elastic carbon nanotube/polydimethylsiloxane composite for wearable electronics.

Implantable devices have provided various potential diagnostic options and therapeutic methods in diverse medical fields. A variety of hard-material-based implantable electrodes have been developed. However, several limitations for their chronic implantation remain, including mechanical mismatches at the interface between the electrode and the soft tissue, and biocompatibility. Soft-material-based implantable devices are suitable candidates for complementing the limitations of hard electrodes. Advances in microtechnology and materials science have largely solved many challenges, such as optimization of shape, minimization of infection, enhancement of biocompatibility and integration with components for diverse functions. Significant strides have also been made in mechanical matching of electrodes to soft tissue. In this review, we provide an overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition. We then review specific applications in three categories: neuroprosthetics, neural signal recording, and neuromodulation. Finally, we describe various strategies for the future development and application of implantable, soft-material-based devices.

Soft implantable microelectrodes for future medicine: prosthetics, neural signal recording and neuromodulation

Diverse commercial implantable medical devices were developed for the convenience and life-quality of patients, and tether-free diagnostics and therapeutics. Those devices need implantable cable, which connects each part of their devices for transcutaneous energy or signal transfer. For prolonged implantation into human body, it should be safe, robust, and be long-term operable without failure. In this paper, we introduce an implantable PDMS-coated cable. By using PDMS as an encapsulation material, we developed a biocompatible, flexible and durable cable. Several tests were carried out for the evaluation of cable performance. Leakage test confirmed that coating using PDMS was sufficient to prevent the invasion of body fluid to conducting wire. Tensile test, torsion-durability test and bending-durability test demonstrated its mechanical durability and robustness to motion. The resistance variation recorded in the durability test was monitored to verify the electrical stability during movement of cable. Experiments of subcutaneous tissue implantation for 8 weeks were performed to observe the degree of biocompatibility as an implantable cable. Our cable was mechanically stable and biocompatible enough to be used for long term implantable medical devices.

Flexible, stretchable and implantable PDMS encapsulated cable for implantable medical device

Piezoelectric polymer-based roadway energy harvesting via displacement amplification module

Alzheimer's disease is accompanied by progressive, time-dependent changes of three moieties of amyloid beta. In vitro models therefore should provide same conditions for more physiologic studies. Here we observed changes in the number of fibrils over time and studied the correlation between amyloid beta moieties and neurotoxicity. Although the number of fibrils increased dramatically, the change in neurotoxicity with time was small, suggesting that fibrils make little contribution to neurotoxicity. To study the neurotoxicity of diffusible moieties by regulating microenvironments, we created a bio-mimetic microfluidic system generating spatial gradients of diffusible oligomeric assemblies and assessed their effects on cultured neurons. We found amyloid beta exposure produced an atrophy effect and observed neurite extension during the differentiation of neural progenitor cells increased when cells were cultured with continuous flow. The results demonstrate the potential neurotoxicity of oligomeric assemblies and establish a prospective microfluidic platform for studying the neurotoxicity of amyloid beta.

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Jeong Hun Kim

Papers

Simple and cost-effective method of highly conductive and elastic carbon nanotube/polydimethylsiloxane composite for wearable electronics.

Soft implantable microelectrodes for future medicine: prosthetics, neural signal recording and neuromodulation

Flexible, stretchable and implantable PDMS encapsulated cable for implantable medical device

Piezoelectric polymer-based roadway energy harvesting via displacement amplification module

Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow.