J
Jeong-In Baek
Researcher at Daegu Haany University
Publications - 32
Citations - 608
Jeong-In Baek is an academic researcher from Daegu Haany University. The author has contributed to research in topics: Hearing loss & Ototoxicity. The author has an hindex of 14, co-authored 28 publications receiving 476 citations. Previous affiliations of Jeong-In Baek include UPRRP College of Natural Sciences & Medical University of South Carolina.
Papers
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Journal ArticleDOI
Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families
Jeong-In Baek,Se-Kyung Oh,Dong-Bin Kim,Soo Young Choi,Un-Kyung Kim,Kyu-Yup Lee,Sang-Heun Lee +6 more
TL;DR: This report is the first documenting the effective use of an NGS technique to detect pathogenic mutations that underlie hearing loss in an East Asian population.
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Effective PEI-mediated delivery of CRISPR-Cas9 complex for targeted gene therapy.
Nari Ryu,Min-A Kim,Dongsik Park,Byeonghyeon Lee,Ye-Ri Kim,Kyung-Hee Kim,Jeong-In Baek,Won Jong Kim,Kyu-Yup Lee,Un-Kyung Kim,Un-Kyung Kim +10 more
TL;DR: It is demonstrated that BPEI-25K is a promising non-viral vector to deliver the CRISPR/Cas9 system in vitro to mediate targeted gene therapy, and these findings contribute to an understanding of CRISpr/ Cas9 delivery that may enable development of successful in vivo techniques.
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Evidence for a founder mutation causing DFNA5 hearing loss in East Asians.
Hong-Joon Park,Hyun-Ju Cho,Jeong-In Baek,Tamar Ben-Yosef,Tamar Ben-Yosef,Tae-Jun Kwon,Andrew J. Griffith,Un-Kyung Kim +7 more
TL;DR: A Korean family with autosomal dominant, progressive and sensorineural hearing loss was ascertained and linkage analysis revealed linkage to the DFNA5 locus on chromosome 7, suggesting that the 3-bp deletion is derived from a single origin in these families.
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Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity
Kyung Hee Kim,Kyung Hee Kim,Byeonghyeon Lee,Byeonghyeon Lee,Ye-Ri Kim,Ye-Ri Kim,Min-A Kim,Min-A Kim,Nari Ryu,Nari Ryu,Da Jung Jung,Un-Kyung Kim,Un-Kyung Kim,Jeong-In Baek,Kyu-Yup Lee +14 more
TL;DR: Alpha-lipoic acid contributes to protecting mitochondrial function by preventing ROS accumulation and inhibiting apoptotic cell death and post-treatment with ALA consistently showed an almost equal restorative effect to pretreatment, in vitro and in vivo, supporting the possible use of ALA as a therapeutic agent for cisplatin-induced ototoxicity.
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Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency
Ye-Ri Kim,Jeong-In Baek,Sung Hwan Kim,Min-A Kim,Byeonghyeon Lee,Nari Ryu,Kyung-Hee Kim,Deok-Gyun Choi,Hye-Min Kim,Michael P. Murphy,Greg Macpherson,Yeon-Sik Choo,Jinwoong Bok,Kyu-Yup Lee,Jeen-Woo Park,Jeen-Woo Park,Un-Kyung Kim,Un-Kyung Kim +17 more
TL;DR: It is identified that IDH2 is indispensable for the functional maintenance and survival of hair cells and SGNs and suggests that Idh2−/− mice could be a valuable animal model for evaluating the therapeutic effects of various antioxidant candidates to overcome ROS-induced hearing loss.