Institution
Daegu Haany University
Education•Daegu, South Korea•
About: Daegu Haany University is a education organization based out in Daegu, South Korea. It is known for research contribution in the topics: Oxidative stress & Acupuncture. The organization has 943 authors who have published 1759 publications receiving 25677 citations.
Topics: Oxidative stress, Acupuncture, Tumor necrosis factor alpha, Proinflammatory cytokine, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: In this review, the materials, fabrication methods, and microparticle structures produced with droplet microfluidics are summarized and a comprehensive overview of their recent uses in biomedical applications is provided.
Abstract: Droplet microfluidics offers exquisite control over the flows of multiple fluids in microscale, enabling fabrication of advanced microparticles with precisely tunable structures and compositions in a high throughput manner The combination of these remarkable features with proper materials and fabrication methods has enabled high efficiency, direct encapsulation of actives in microparticles whose features and functionalities can be well controlled These microparticles have great potential in a wide range of bio-related applications including drug delivery, cell-laden matrices, biosensors and even as artificial cells In this review, we briefly summarize the materials, fabrication methods, and microparticle structures produced with droplet microfluidics We also provide a comprehensive overview of their recent uses in biomedical applications Finally, we discuss the existing challenges and perspectives to promote the future development of these engineered microparticles
363 citations
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TL;DR: The results suggest that nano‐TiO2 induces ROS generation in lymphocytes, thereby activating p53‐mediated DNA damage checkpoint signals, and thus inducing cytotoxic effects in peripheral blood lymphocytes.
Abstract: Titanium dioxide nanoparticles (nano-TiO2) are widely used as a photocatalyst in air and water remediation. These nanoparticles are known to induce toxicity; however, their cytotoxic mechanism is not fully understood. In this study, we investigated the underlying mechanism of nano-TiO2-induced cytotoxicity in peripheral blood lymphocytes. We examined the genotoxic effects of nano-TiO2 in lymphocytes using alkaline single-cell gel electrophoresis (Comet) and cytokinesis-block micronucleus (CBMN) assays. Lymphocytes treated with nano-TiO2 showed significantly increased micronucleus formation and DNA breakage. Western-blot analysis to identify proteins involved in the p53-mediated response to DNA damage revealed the accumulation of p53 and activation of DNA damage checkpoint kinases in nano-TiO2-treated lymphocytes. However, p21 and bax, downstream targets of p53, were not affected, indicating that nano-TiO2 does not stimulate transactivational activity of p53. The generation of reactive oxygen species (ROS) in nano-TiO2-treated cells was also observed, andN-acetylcysteine (NAC) supplementation inhibited the level of nano-TiO2-induced DNA damage. Given that ROS-induced DNA damage leads to p53 activation in the DNA damage response, our results suggest that nano-TiO2 induces ROS generation in lymphocytes, thereby activating p53-mediated DNA damage checkpoint signals.
332 citations
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TL;DR: In this paper, a study of the tensile fracture properties of UHPFRC considering the effects of the fiber content is presented, and a tri-linear tensile softening model is suggested.
310 citations
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TL;DR: ZnO NPs demonstrated moderate antioxidant activity by scavenging 45.47% DPPH at 1mg/mL and revealed excellent anti-inflammatory activity by dose-dependently suppressing both mRNA and protein expressions of iNOS, COX-2,IL-1β, IL-6 and TNF-α.
Abstract: The exploitation of various plant materials for the green synthesis of nanoparticles is considered an eco-friendly technology because it does not involve toxic chemicals. In this study, zinc oxide nanoparticles (ZnO NPs) were synthesized using the root extract of Polygala tenuifolia. Synthesized ZnO NPs were characterized by UV-Vis spectroscopy, FTIR, TGA, TEM, SEM and EDX. Anti-inflammatory activity was investigated in LPS-stimulated RAW 264.7 macrophages, whereas antioxidant activity was examined using a DPPH free radical assay. ZnO NPs demonstrated moderate antioxidant activity by scavenging 45.47% DPPH at 1mg/mL and revealed excellent anti-inflammatory activity by dose-dependently suppressing both mRNA and protein expressions of iNOS, COX-2, IL-1β, IL-6 and TNF-α.
305 citations
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TL;DR: In wound healing test, this minocycline-loaded PVA-chitosan hydrogel showed faster healing of the wound made in rat dorsum than the conventional product or the control (sterile gauze) due to antifungal activity of chitOSan.
276 citations
Authors
Showing all 946 results
Name | H-index | Papers | Citations |
---|---|---|---|
Surendra P. Shah | 99 | 710 | 32832 |
Jin Mo Chung | 65 | 146 | 20501 |
Kyungsoon Chung | 51 | 104 | 7013 |
Jong-Sup Bae | 46 | 310 | 7017 |
Sae-Kwang Ku | 45 | 468 | 8295 |
Takako Yokozawa | 44 | 180 | 6172 |
Jinhee Kim | 35 | 329 | 5089 |
Tae Hoon Kim | 30 | 175 | 2865 |
Liberato Ferrara | 30 | 190 | 3438 |
Sang Chan Kim | 28 | 156 | 2629 |
Chang-Hyung Choi | 25 | 63 | 2189 |
Il Je Cho | 24 | 92 | 1895 |
Hongsik Choi | 23 | 85 | 1871 |
Chae Ha Yang | 23 | 108 | 2055 |
Hong Kim | 23 | 82 | 1709 |