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Se-Kyung Oh
Researcher at UPRRP College of Natural Sciences
Publications - 11
Citations - 294
Se-Kyung Oh is an academic researcher from UPRRP College of Natural Sciences. The author has contributed to research in topics: Hearing loss & Methionine sulfoxide reductase. The author has an hindex of 8, co-authored 11 publications receiving 249 citations. Previous affiliations of Se-Kyung Oh include Kyungpook National University.
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Journal ArticleDOI
Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families
Jeong-In Baek,Se-Kyung Oh,Dong-Bin Kim,Soo Young Choi,Un-Kyung Kim,Kyu-Yup Lee,Sang-Heun Lee +6 more
TL;DR: This report is the first documenting the effective use of an NGS technique to detect pathogenic mutations that underlie hearing loss in an East Asian population.
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Methionine Sulfoxide Reductase B3-Targeted In Utero Gene Therapy Rescues Hearing Function in a Mouse Model of Congenital Sensorineural Hearing Loss.
Min-A Kim,Hyun-Ju Cho,Seung-Hyun Bae,Byeonghyeon Lee,Se-Kyung Oh,Tae-Jun Kwon,Zae Young Ryoo,Hwa-Young Kim,Jin-Ho Cho,Un-Kyung Kim,Kyu-Yup Lee +10 more
TL;DR: This is the first study to demonstrate functional and morphological rescue of the hair cells of the inner ear in the MsrB3 deficiency mouse model of congenital genetic sensorineural hearing loss using an in utero, virus-mediated gene therapy approach.
Journal ArticleDOI
Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells
Tae-Jun Kwon,Hyun-Ju Cho,Un-Kyung Kim,Eujin Lee,Se-Kyung Oh,Jinwoong Bok,Yong Chul Bae,Junkoo Yi,Jang-Woo Lee,Zae Young Ryoo,Sang-Heun Lee,Kyu-Yup Lee,Hwa-Young Kim +12 more
TL;DR: The data suggest that MsrB3 plays an essential role in maintaining the integrity of hair cells, possibly explaining the pathogenesis of DFNB74 deafness in humans caused by MSRB3 deficiency.
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Pannexin 3 is required for normal progression of skeletal development in vertebrates
Se-Kyung Oh,Jeong Oh Shin,Jeong-In Baek,Jinwook Lee,Jae Woong Bae,Harinarayana Ankamerddy,Myoung-Jin Kim,Tae-Lin Huh,Zae Young Ryoo,Un-Kyung Kim,Jinwoong Bok,Kyu-Yup Lee +11 more
TL;DR: Evidence is provided of the crucial roles of Panx3 in vertebrate skeletal development in vivo and the abnormal progression of hypertrophic chondrogenesis appeared to be associated with the sustained proliferation of chondrocytes, which resulted from increased intracellular cAMP levels.
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Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures
TL;DR: It is suggested that galangin can potentially be used as an antioxidant and antiapoptotic agent to prevent hearing loss caused by aminoglycoside induced-oxidative stress.