The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

CA : A Cancer Journal for Clinicians

A review of shape memory alloy research, applications and opportunities

https://www.gastrojournal.org/article/S0016-5085(10)00878-4/pdf

Infections in Patients With Cirrhosis Increase Mortality Four-Fold and Should Be Used in Determining Prognosis

Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree Their incidence is increasing globally, currently accounting for ~15% of all primary liver cancers and ~3% of gastrointestinal malignancies The silent presentation of these tumours combined with their highly aggressive nature and refractoriness to chemotherapy contribute to their alarming mortality, representing ~2% of all cancer-related deaths worldwide yearly The current diagnosis of CCA by non-invasive approaches is not accurate enough, and histological confirmation is necessary Furthermore, the high heterogeneity of CCAs at the genomic, epigenetic and molecular levels severely compromises the efficacy of the available therapies In the past decade, increasing efforts have been made to understand the complexity of these tumours and to develop new diagnostic tools and therapies that might help to improve patient outcomes In this expert Consensus Statement, which is endorsed by the European Network for the Study of Cholangiocarcinoma, we aim to summarize and critically discuss the latest advances in CCA, mostly focusing on classification, cells of origin, genetic and epigenetic abnormalities, molecular alterations, biomarker discovery and treatments Furthermore, the horizon of CCA for the next decade from 2020 onwards is highlighted

/pdf/cholangiocarcinoma-2020-the-next-horizon-in-mechanisms-and-4ua2gtq2hw.pdf

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

Factors affecting insertion time and patient discomfort during colonoscopy.

Association between hepatitis B virus infection and HLA-DR type in Korea.

https://www.giejournal.org/article/S0016-5107(08)01778-1/pdf

First clinical trial of the “MiRo” capsule endoscope by using a novel transmission technology: electric-field propagation

Active locomotion of a paddling-based capsule endoscope in an in vitro and in vivo experiment (with videos).

Objective:To characterize the role of Oct4 and Nanog, two important homeobox transcription factors of embryonic development, in pancreatic carcinogenesis.Methods:Using a tissue microarray of human pancreatic carcinoma and adjacent noncancerous tissues as well as the N-nitrosobis(2-oxopropyl)amine-in

Jeong Youp Park

Papers

Factors affecting insertion time and patient discomfort during colonoscopy.

Association between hepatitis B virus infection and HLA-DR type in Korea.

First clinical trial of the “MiRo” capsule endoscope by using a novel transmission technology: electric-field propagation

Active locomotion of a paddling-based capsule endoscope in an in vitro and in vivo experiment (with videos).

Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis.