J
Jérémie Roux
Researcher at French Institute of Health and Medical Research
Publications - 10
Citations - 58
Jérémie Roux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Drug resistance & Cell migration. The author has an hindex of 4, co-authored 10 publications receiving 37 citations. Previous affiliations of Jérémie Roux include University of Paris.
Papers
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Journal ArticleDOI
Profiling the Non-genetic Origins of Cancer Drug Resistance with a Single-Cell Functional Genomics Approach Using Predictive Cell Dynamics
Mickael Meyer,Agnès Paquet,Marie-Jeanne Arguel,Ludovic Peyre,Luis C. Gomes-Pereira,Kevin Lebrigand,Baharia Mograbi,Patrick Brest,Rainer Waldmann,Pascal Barbry,Paul Hofman,Jérémie Roux +11 more
TL;DR: The same-cell approach, named fate-seq, can reveal the molecular factors regulating the efficacy of a drug in clonal cells, providing therapeutic targets of non-genetic drug resistance otherwise confounded in gene expression noise.
Journal ArticleDOI
TRAIL receptor-induced features of epithelial-to-mesenchymal transition increase tumour phenotypic heterogeneity: potential cell survival mechanisms.
TL;DR: The molecular mechanisms by which death signals can elicit an increase in response heterogeneity in the metastasis context are explored, and the impact of these processes on cell responses to cancer therapeutics is evaluated.
Journal ArticleDOI
Autophagy : Moving Benchside Promises to Patient Bedsides.
Amine Belaid,Papa Diogop Ndiaye,Harilaos Filippakis,Jérémie Roux,Eric Rottinger,Yacine Graba,Patrick Brest,Paul Hofman,Baharia Mograbi +8 more
TL;DR: An overview of the contradictory roles that autophagy plays in cancer initiation and progression is provided and the promises and challenges of current strategies that target autophagic for cancer therapy are discussed.
Posted Content
An Atlas of the Genetic Variations Linking Dysregulation of Autophagy to Human Diseases: The Missing Environmental Link
Iris Grosjean,Barnabé Roméo,Marie-Angela Domdom,Nathalie Yazbeck,Grégoire D'Andréa,Amine Belaid,Olivier Camuzard,Olivia Vidal,Guillemette Crépeaux,Romain K. Gherardi,François-Jérôme Authier,Jean Daniel Masson,Eric Gilson,Charles-Hugo Marquette,Sylvie Leroy,Jérémie Roux,Patrick Brest,Martin Von Bergen,Gérard Milano,Daniel J. Klionsky,Paul Hofman,Baharia Mograbi +21 more
TL;DR: Iris Grosjean, Barnabé Roméo, Marie-Angela Domdom, Nathalie Yazbeck, Grégoire D’Andréa, Olivia Vidal, Guillemette Crépeaux, Romain K Gherardi, Sylvie Leroy, Jérémie Roux 1, Patrick Brest, Martin Von Bergen, Gérard Milano, Daniel J. Klionsky, Paul Hofman.
Book ChapterDOI
Core Models of Receptor Reactions to Evaluate Basic Pathway Designs Enabling Heterogeneous Commitments to Apoptosis
TL;DR: In this paper, the core reactions leading to caspase-8 activation, based on mass-action kinetics models, were investigated to evaluate the basic mechanisms giving rise to the observed heterogeneous response.