Jeremy J Heit

TL;DR: Endovascular thrombectomy for ischemic stroke 6 to 16 hours after a patient was last known to be well plus standard medical therapy resulted in better functional outcomes than standard medical Therapy alone among patients with proximal middle‐cerebral‐artery or internal‐carotid‐arterY occlusion and a region of tissue that was ischeMIC but not yet infarcted.

TL;DR: It is suggested that the 1.5-fold increase in dosage of DSCR1 and DYRK1A cooperatively destabilizes a regulatory circuit, leading to reduced NFATc activity and many of the features of Down's syndrome, and the destabilization of regulatory circuits can underlie human disease.

TL;DR: Evidence is provided that embryonic stem cells can serve as the source of insulin-producing replacement tissue in an experimental model of diabetes mellitus and that strategies for producing cells that can replace islet functions described here can be adapted for similar uses with human cells.

TL;DR: Calcineurin/NFAT signalling regulates multiple factors that control growth and hallmark β-cell functions, revealing unique models for the pathogenesis and therapy of diabetes.

TL;DR: It is shown that menin, a protein previously characterized as an endocrine tumor suppressor and transcriptional regulator, controls islet growth in pregnant mice, expanding the understanding of mechanisms underlying diabetes pathogenesis and revealing potential targets for therapy in diabetes.