J
Jeremy R. Graff
Researcher at Eli Lilly and Company
Publications - 95
Citations - 17908
Jeremy R. Graff is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Cancer & Immune system. The author has an hindex of 38, co-authored 86 publications receiving 17324 citations. Previous affiliations of Jeremy R. Graff include University of California, San Francisco & Johns Hopkins University.
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Journal ArticleDOI
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
TL;DR: The use of MSP is demonstrated to identify promoter region hypermethylation changes associated with transcriptional inactivation in four important tumor suppressor genes (p16, p15, E-cadherin and von Hippel-Lindau) in human cancer.
Book ChapterDOI
Alterations in dna methylation : a fundamental aspect of neoplasia
TL;DR: A model is proposed wherein tumor progression results from episodic clonal expansion of heterogeneous cell populations driven by continuous interaction between these methylation abnormalities and classic genetic changes.
Journal ArticleDOI
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
James G. Herman,Asad Umar,Kornelia Polyak,Jeremy R. Graff,Nita Ahuja,Jean Pierre J. Issa,Sanford Markowitz,Sanford Markowitz,James K V Willson,Stanley R. Hamilton,Kenneth W. Kinzler,Michael F. Kane,Richard D. Kolodner,Bert Vogelstein,Thomas A. Kunkel,Stephen B. Baylin +15 more
TL;DR: The results suggest that microsatellite instability in sporadic colorectal cancer often results from epigenetic inactivation of hMLH1 in association with DNA methylation.
Journal Article
E-Cadherin Expression Is Silenced by DNA Hypermethylation in Human Breast and Prostate Carcinomas
Jeremy R. Graff,James G. Herman,Rena G. Lapidus,Hemi Chopra,Rosa Xu,David F. Jarrard,William B. Isaacs,Paula M. Pitha,Nancy E. Davidson,Stephen B. Baylin +9 more
TL;DR: The data demonstrate that frequent loss of E-cad expression in human breast and prostate carcinomas results from hypermethylation of the E- cad promoter region.
Journal ArticleDOI
eIF-4E expression and its role in malignancies and metastases.
TL;DR: A deeper understanding of the role of eIF-4E in regulating the translation of the diverse gene products involved in all aspects of malignancy will improve the capacity to exploit eIF -4E as a therapeutic target and as a marker for human cancer progression.