J
Jeremy S. Paige
Researcher at Cornell University
Publications - 11
Citations - 2316
Jeremy S. Paige is an academic researcher from Cornell University. The author has contributed to research in topics: Fluorophore & Aptamer. The author has an hindex of 8, co-authored 9 publications receiving 2037 citations.
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Journal ArticleDOI
RNA Mimics of Green Fluorescent Protein
TL;DR: The generation of RNA aptamers that bind fluorophores resembling the fluorophore in GFP provide an approach for genetic encoding of fluorescent RNAs and create a palette that spans the visible spectrum.
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Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
TL;DR: Ubiquitin remnant profiling of the multi-ubiquitinated proteins proliferating cell nuclear antigen (PCNA) and tubulin α-1A reveals differential regulation of ubiquitination at specific sites by microtubule inhibitors, demonstrating the effectiveness of the method to characterize the dynamics of lysine ubiquitinations.
Journal ArticleDOI
Fluorescence Imaging of Cellular Metabolites with RNA
TL;DR: An approach for generating fluorescent sensors based on Spinach, an RNA sequence that binds and activates the fluorescence of a small-molecule fluorophore is described, showing that these sensors can detect a variety of different small molecules in vitro and in living cells.
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Nitrosothiol Reactivity Profiling Identifies S-Nitrosylated Proteins with Unexpected Stability
TL;DR: It is shown that although most protein nitrosothiols are rapidly degraded by cytosolic reductants, a small subset form unusually stable S-nitrosylated proteins, likely to mediate the persistent cellular effects of NO.
Journal ArticleDOI
Pharmacologic manipulation of nitric oxide signaling: targeting NOS dimerization and protein-protein interactions.
Jeremy S. Paige,Samie R. Jaffrey +1 more
TL;DR: Emerging approaches in the development of isoform-specific NOS-directed therapeutics including dimerization inhibitors, novel L-arginine (L-Arg) binding site inhibitors, and dimer stabilization are discussed.