J
Jeroen W. J. van Heijst
Researcher at University of Amsterdam
Publications - 24
Citations - 1722
Jeroen W. J. van Heijst is an academic researcher from University of Amsterdam. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 15, co-authored 23 publications receiving 1513 citations. Previous affiliations of Jeroen W. J. van Heijst include VU University Medical Center & Netherlands Cancer Institute.
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Journal ArticleDOI
Heterogeneous differentiation patterns of individual CD8+ T cells.
Carmen Gerlach,Jan Rohr,Jan Rohr,Leïla Perié,Leïla Perié,Nienke van Rooij,Jeroen W. J. van Heijst,Arno Velds,Jos Urbanus,Shalin H. Naik,Heinz Jacobs,Joost B. Beltman,Joost B. Beltman,Rob J. de Boer,Ton N. Schumacher +14 more
TL;DR: It is demonstrated that, even for T cells bearing identical T cell receptors, both clonal expansion and differentiation patterns are heterogeneous, and individual naïve T lymphocytes contributed differentially to short- and long-term protection, as revealed by participation of their progeny during primary versus recall infections.
Journal ArticleDOI
One naive T cell, multiple fates in CD8+ T cell differentiation
Carmen Gerlach,Jeroen W. J. van Heijst,Erwin Swart,Daoud Sie,Nicola J. Armstrong,Ron M. Kerkhoven,Dietmar Zehn,Michael J. Bevan,Koen Schepers,Ton N. Schumacher +9 more
TL;DR: It is demonstrated that under all conditions tested, individual naive T cells yield both effector and memory CD8+ T cell progeny, which indicates that effectors and memory fate decisions are not determined by the nature of the priming antigen-presenting cell or the time of T cell priming.
Journal ArticleDOI
Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation
Jeroen W. J. van Heijst,Izaskun Ceberio,Lauren Lipuma,Dane W Samilo,Gloria Wasilewski,Anne Marie Gonzales,Jimmy Nieves,Marcel R.M. van den Brink,Marcel R.M. van den Brink,Miguel Perales,Miguel Perales,Eric G. Pamer +11 more
TL;DR: The combined use of 5′ rapid amplification of complementary DNA ends PCR with deep sequencing to quantify TCR diversity in 28 recipients of allo-HSCT using a single oligonucleotide pair provides unprecedented views of T cell repertoire recovery after allo -HSCT and may identify patients at high risk of infection or relapse.
Journal ArticleDOI
A Gamma Interferon Independent Mechanism of CD4 T Cell Mediated Control of M. tuberculosis Infection in vivo
Alena M. Gallegos,Alena M. Gallegos,Jeroen W. J. van Heijst,Miriam Samstein,Xiaodi Su,Eric G. Pamer,Michael S. Glickman +6 more
TL;DR: Results imply a previously unrecognized IFNγ/TNF independent pathway that efficiently controls Mtb and suggest that optimization of this alternative effector function may provide new therapeutic avenues to combat Mtb through vaccination.
Journal ArticleDOI
Recruitment of Antigen-Specific CD8+ T Cells in Response to Infection Is Markedly Efficient
Jeroen W. J. van Heijst,Carmen Gerlach,Erwin Swart,Daoud Sie,Cláudio Nunes-Alves,Ron M. Kerkhoven,Ramon Arens,Margarida Correia-Neves,Koen Schepers,Ton N. Schumacher +9 more
TL;DR: Naïve T cell recruitment is highly efficient, and the magnitude of antigen-specific CD8+ T cell responses is primarily controlled by clonal expansion, which is determined by labeling naïve T cells with unique genetic tags and transferring them into mice.