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Rob J. de Boer

Researcher at Utrecht University

Publications -  294
Citations -  18716

Rob J. de Boer is an academic researcher from Utrecht University. The author has contributed to research in topics: Population & T cell. The author has an hindex of 66, co-authored 282 publications receiving 17245 citations. Previous affiliations of Rob J. de Boer include Santa Fe Institute & Eötvös Loránd University.

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Journal ArticleDOI

Lead times and overdetection due to prostate-specific antigen screening: estimates from the European Randomized Study of Screening for Prostate Cancer.

Gerrit Draisma, +6 more
- 18 Jun 2003 - 
TL;DR: In this paper, the authors developed simulation models based on results of the Rotterdam section of the European Randomized Study of Prostate Cancer (ERSPC), which enrolled 42,376 men and in which 1498 cases of prostate cancer were identified.
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Dynamics of HIV infection of CD4+ T cells

Alan S. Perelson, +2 more
- 01 Mar 1993 - 
TL;DR: A model for the interaction of HIV with CD4+ T cells that considers four populations, characterized by generating differing numbers of infective virions within infected T cells, can cause different amounts of T-cell depletion and generate depletion at different rates.
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Overdiagnosis Due to Prostate-Specific Antigen Screening: Lessons From U.S. Prostate Cancer Incidence Trends

Ruth Etzioni, +6 more
- 03 Jul 2002 - 
TL;DR: The results suggest that the majority of screen-detected cancers diagnosed between 1988 and 1998 would have presented clinically and that only a minority of cases found at autopsy would have been detected by PSA testing.
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Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation

Nadine Pakker, +9 more
- 01 Feb 1998 - 
TL;DR: It is shown, using mathematical modeling, that redistribution of T cells to the blood can explain the striking correlation between the initial CD4+ and CD8+ memory T-cell repopulation and the observation that 3 weeks after the start of treatment memory CD4-cell numbers reach a plateau.
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In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.

Janesh Pillay, +7 more
- 29 Jul 2010 - 
TL;DR: It is shown that in vivo labeling in humans with the use of (2)H(2)O under homeostatic conditions showed an average circulatory neutrophil lifespan of 5.4 days, which is at least 10 times longer than previously reported and might lead to reappraisal of novel neutrophils functions in health and disease.