J
Jerome J. A. Hendriks
Researcher at University of Hasselt
Publications - 83
Citations - 3169
Jerome J. A. Hendriks is an academic researcher from University of Hasselt. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Multiple sclerosis. The author has an hindex of 30, co-authored 74 publications receiving 2489 citations. Previous affiliations of Jerome J. A. Hendriks include VU University Amsterdam & Transnational University Limburg.
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Journal ArticleDOI
Microglial derived extracellular vesicles activate autophagy and mediate multi-target signaling to maintain cellular homeostasis
Bram Van den Broek,Isabel Pintelon,Ibrahim Hamad,Sofie Kessels,Mansour Haidar,Niels Hellings,Jerome J. A. Hendriks,Markus Kleinewietfeld,Bert Brône,Vincent Timmerman,Jean-Pierre Timmermans,Veerle Somers,Luc Michiels,Joy Irobi +13 more
TL;DR: It is demonstrated that in vitro produced microglial EVs are able to influence multiple biological pathways and promote activation of autophagy in order to maintain microglia survival and homeostasis.
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Inflammation at the blood-brain barrier: The role of liver X receptors.
TL;DR: The potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases is discussed.
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Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system.
Gemma Llufriu-Dabén,Alex Carrete,Elena Chierto,Jo Mailleux,Emeline Camand,Anne Simon,Tim Vanmierlo,Christiane Rose,Bernadette Allinquant,Jerome J. A. Hendriks,Charbel Massaad,Delphine Meffre,Mehrnaz Jafarian-Tehrani +12 more
TL;DR: Etazolate-induced sAPPα release protects myelinated axons from demyelination while also promoting remyelinated disorders, and highlights the therapeutic potential of strategies that enhance sAPP α release in demYelinating disorders.
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Phloretin suppresses neuroinflammation by autophagy-mediated Nrf2 activation in macrophages.
Tess Dierckx,Mansour Haidar,Elien Grajchen,Elien Wouters,Sam Vanherle,Melanie Loix,Annick Boeykens,Dany Bylemans,Kévin Hardonnière,Saadia Kerdine-Römer,Jeroen F. J. Bogie,Jerome J. A. Hendriks +11 more
TL;DR: In this article, the authors investigated if and how phloretin, a flavonoid abundantly present in apples and strawberries, lowers the inflammatory phenotype of macrophages and suppresses neuroinflammation.
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Extracellular vesicle-associated lipids in central nervous system disorders.
TL;DR: It is concluded that EV-associated lipids are closely associated with neuroinflammation, CNS repair, and pathological protein aggregation in CNS disorders, and that modulation of the EV lipidome represents a promising therapeutic strategy to halt disease progression in multiple sclerosis, Alzheimer's, and Parkinson's disease.