C
Charbel Massaad
Researcher at Paris Descartes University
Publications - 72
Citations - 2623
Charbel Massaad is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Myelin & Wnt signaling pathway. The author has an hindex of 25, co-authored 69 publications receiving 2069 citations. Previous affiliations of Charbel Massaad include University of Paris-Sud & University of Paris.
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Journal ArticleDOI
Tissue damage from neutrophil-induced oxidative stress in COVID-19.
Mireille Laforge,Carole Elbim,Corinne Frere,Miryana Hémadi,Charbel Massaad,Philippe Nuss,Jean-Jacques Benoliel,Chrystel Becker +7 more
TL;DR: It is suggested that free radical scavengers could be beneficial for the most vulnerable patients with COVID-19, because of how the excessive release of reactive oxygen species by neutrophils may perpetuate red blood cell dysfunction, thrombosis and tissue damage in severe cases of COIDs.
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Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
Thierry Bordet,Bruno Buisson,Magali Michaud,Cyrille Drouot,Pascale Galéa,Pierre Delaage,Natalia P. Akentieva,Alex S. Evers,Douglas F. Covey,Mariano A. Ostuni,Jean-Jacques Lacapère,Charbel Massaad,Michael Schumacher,Esther-Marie Steidl,Delphine Maux,Michel Delaage,Christopher E. Henderson,Rebecca M. Pruss +17 more
TL;DR: In vivo and in vitro, TRO19622 rescued motor neurons from axotomy-induced cell death in neonatal rats and promoted nerve regeneration following sciatic nerve crush in mice, suggesting a potential mechanism for its neuroprotective activity.
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Wnt/beta-catenin signaling is an essential and direct driver of myelin gene expression and myelinogenesis.
Marcel Tawk,Joelle Makoukji,Martin Belle,Cosima Fonte,Amalia Trousson,Thomas A. Hawkins,Huiliang Li,Said Ghandour,Michael Schumacher,Charbel Massaad +9 more
TL;DR: Loss-of-function analyses in zebrafish embryos show a key role for Wnt/β-catenin signaling in the expression of myelin genes and in myelin sheath compaction, both in the peripheral and central nervous systems.
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Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.
Michael Schumacher,Rachida Guennoun,Abdel M. Ghoumari,Charbel Massaad,Françoise Robert,Martine El-Etr,Yvette Akwa,Krzysztof Rajkowski,Etienne-Emile Baulieu +8 more
TL;DR: The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials, and the recognition that progesterone is synthesized by neurons and glial cells requires a reevaluation of hormonal aging.
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Lithium enhances remyelination of peripheral nerves
Joelle Makoukji,Martin Belle,Delphine Meffre,Ruth M. Stassart,Julien Grenier,Ghjuvan’ Ghjacumu Shackleford,Robert Fledrich,Cosima Fonte,Julien Branchu,Marie Goulard,Catherine de Waele,Frédéric Charbonnier,Michael W. Sereda,Etienne-Emile Baulieu,Michael Schumacher,Sophie Bernard,Charbel Massaad +16 more
TL;DR: It is shown by ChIP experiments that LiCl treatment drives β-catenin to bind to T-cell factor/lymphoid-enhancer factor response elements identified in myelin genes, which opens perspectives in the treatment of nerve demyelination by administering GSK3β inhibitors such as lithium.