J
Jerry L. Slightom
Researcher at Upjohn
Publications - 162
Citations - 13984
Jerry L. Slightom is an academic researcher from Upjohn. The author has contributed to research in topics: Gene & Nucleic acid sequence. The author has an hindex of 63, co-authored 162 publications receiving 13785 citations. Previous affiliations of Jerry L. Slightom include University of Wisconsin-Madison & Cornell University.
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Journal ArticleDOI
The structure and evolution of the human β-globin gene family
Argiris Efstratiadis,James W. Posakony,Tom Maniatis,Richard M. Lawn,Catherine O'Connell,Richard A. Spritz,Jon K. deRiel,Bernard G. Forget,Sherman M. Weissman,Jerry L. Slightom,Ann E. Blechl,Oliver Smithies,Francisco E. Baralle,Carol C. Shoulders,Nick J. Proudfoot +14 more
TL;DR: A model for the involvement of short direct repeat sequences in the generation of deletions in the noncoding and coding regions of B-like globin genes during evolution is described.
The Structure and Evolution of the Human /?-Globin Gene Family
Argiris Efstratiadis,James W. Posakony,Tom Maniatis,Richard M. Lawn,Richard A. Spritz,Jon K. deRiel,Forget Bg,Sherman M. Weissman,Jerry L. Slightom,Ann E. Blechl,Oliver Smithies,F.E. Baralle,Carol C. Shoulders,Nicholas J. ProudfootQ +13 more
TL;DR: Efstratiadis et al. as mentioned in this paper presented the results of a detailed comparison of the primary structure of human p-like globin genes and their flanking sequences.
Journal ArticleDOI
Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes
TL;DR: The sequence data suggest that intergenic conversions occur in the germ line, and strongly suggest that DNA sequence polymorphisms for localized deletions, additions and base substitutions are very common in human populations.
Journal ArticleDOI
Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein
Donald B. Carter,Martin R. Deibel,Colin J. Dunn,Che-Shen C. Tomich,Alice L. Laborde,Jerry L. Slightom,Ann E. Berger,Michael J. Bienkowski,Frank F. Sun,Robert N. McEwan,Peter K. W. Harris,Anthony W. Yem,G. A. Waszak,J G Chosay,L. C. Sieu,M. M. Hardee,H. A. Zurcher-Neely,I M Reardon,Robert L. Heinrikson,Scott E. Truesdell,J. A. Shelly,Thomas E. Eessalu,B. M. Taylor,Daniel E. Tracey +23 more
TL;DR: A human myelomonocytic cell line, U937, produced an interleukin-1 (IL-1) receptor antagonist protein (IRAP) which was purified and partially sequenced and was a potent inhibitor of IL-1 induced corticosterone production in vivo.
Journal ArticleDOI
Nucleotide sequence analysis of TL-DNA of Agrobacterium rhizogenes agropine type plasmid. Identification of open reading frames.
TL;DR: Comparison of Ri TL-DNA coding and noncoding sequence regions with T-DNA sequence regions from octopine type Ti plasmid pTi15955 reveals no extensive sequence homologies.