J
Jesse Aaron
Researcher at Howard Hughes Medical Institute
Publications - 88
Citations - 3627
Jesse Aaron is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Focal adhesion & Medicine. The author has an hindex of 21, co-authored 74 publications receiving 3155 citations. Previous affiliations of Jesse Aaron include Sandia National Laboratories & University of Texas at Austin.
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Journal Article
Real-Time Vital Optical Imaging of Precancer Using Anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles
Konstantin V Sokolov,Michele Follen,Jesse Aaron,Ina Pavlova,Anais Malpica,Reuben Lotan,Rebecca Richards-Kortum +6 more
TL;DR: A new class of molecular specific contrast agents for vital reflectance imaging based on gold nanoparticles attached to probe molecules with high affinity for specific cellular biomarkers is described and it is shown that gold conjugates can be delivered topically for imaging throughout the whole epithelium.
Journal ArticleDOI
Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties
TL;DR: A novel conjugation technique to control the binding orientation of antibodies on the surface of gold nanoparticles to maximize antibody functionality and a method to prepare multifunctional nanoparticles by incorporating targeting and delivery moieties on the same nanoparticle that addresses the challenge of imaging intracellular biomarkers.
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Optical systems for in vivo molecular imaging of cancer.
Konstantin V Sokolov,Jesse Aaron,Betsy Hsu,Dawn L. Nida,Ann M. Gillenwater,Michele Follen,Calum MacAulay,Karen Adler-Storthz,Brian A. Korgel,Michael R. Descour,Renata Pasqualini,Wadih Arap,Wan L. Lam,Rebecca Richards-Kortum +13 more
TL;DR: A comprehensive strategy to develop inexpensive, rugged and portable optical imaging systems for molecular imaging of cancer, which couples the development of optically active contrast agents with advances in functional genomics of cancer.
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Molecular specific optoacoustic imaging with plasmonic nanoparticles.
TL;DR: The results of this study demonstrate that the combination of anti-EGFR gold ioconjugates and optoacoustic imaging can allow highly sensitive and selective detection of human epithelial cancer cells.
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Hybrid plasmonic magnetic nanoparticles as molecular specific agents for MRI/optical imaging and photothermal therapy of cancer cells
TL;DR: It is shown that receptor-mediated aggregation of anti-EGFR hybrid nanoparticles allows selective destruction of highly proliferative cancer cells using a nanosecond pulsed laser at 700?nm wavelength, a significant shift from the peak absorbance of isolated hybrid nanoparticle at 532?nm.