W
Wan L. Lam
Researcher at BC Cancer Research Centre
Publications - 313
Citations - 22171
Wan L. Lam is an academic researcher from BC Cancer Research Centre. The author has contributed to research in topics: Cancer & Comparative genomic hybridization. The author has an hindex of 72, co-authored 297 publications receiving 20104 citations. Previous affiliations of Wan L. Lam include Dalhousie University & BC Cancer Agency.
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Journal ArticleDOI
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells.
Michael Weber,Jonathan J. Davies,David Wittig,Edward J. Oakeley,Michael Haase,Wan L. Lam,Dirk Schübeler +6 more
TL;DR: Analysis of 6,000 CpG islands showed that only a small set of promoters was methylated differentially, suggesting that aberrant methylation of CpGs island promoters in malignancy might be less frequent than previously hypothesized.
Journal ArticleDOI
The functional role of long non-coding RNA in human carcinomas
TL;DR: The emerging functional role of lncRNAs in human cancer is highlighted and molecular mechanisms by which these RNA species function are described, providing insight into the functional roles they may play in tumorigenesis.
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A tiling resolution DNA microarray with complete coverage of the human genome.
Adrian Ishkanian,Chad A. Malloff,Spencer Watson,Ronald J. deLeeuw,Bryan Chi,Bradley P. Coe,Antoine M. Snijders,Donna G. Albertson,Daniel Pinkel,Marco A. Marra,Victor Ling,Calum MacAulay,Wan L. Lam +12 more
TL;DR: The constructed tiling resolution array allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease and shows the need to move beyond conventional marker-based genome comparison approaches, that rely on inference of continuity between interval markers.
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Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Daniel T. Starczynowski,Florian Kuchenbauer,Bob Argiropoulos,Sandy Sung,Ryan D. Morin,Andrew L Muranyi,Martin Hirst,Donna E. Hogge,Marco A. Marra,Richard A. Wells,Rena Buckstein,Wan L. Lam,R. Keith Humphries,Aly Karsan +13 more
TL;DR: Deletes chromosome 5q and identifies Toll–interleukin-1 receptor domain–containing adaptor protein (TIRAP) and tumor necrosis factor receptor–associated factor-6 (TRAF6) as respective targets of these miRNAs.
Journal ArticleDOI
A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome
Kendy K. Wong,Ronald J. deLeeuw,Nirpjit S. Dosanjh,Lindsey R. Kimm,Ze Cheng,Douglas E. Horsman,Calum MacAulay,Raymond T. Ng,Carolyn J. Brown,Evan E. Eichler,Wan L. Lam +10 more
TL;DR: An in-depth survey of CNVs across the human genome provides a valuable baseline for studies involving human genetics and raises the possibility of the contribution of microRNAs to phenotypic diversity in humans.